15 Papers
8 Citations
Long Gui is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Biology & Flagellum. The author has an hindex of 3, co-authored 7 publications.
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Papers
Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation.
Christian Trötschel,Hussein Hamzeh,Hussein Hamzeh,Luis Alvarez,René Pascal,Fedir Lavryk,Wolfgang Bönigk,Heinz G. Körschen,Astrid Müller,Ansgar Poetsch,Andreas Rennhack,Long Gui,Daniela Nicastro,Timo Strünker,Timo Strünker,Reinhard Seifert,Reinhard Seifert,U. Benjamin Kaupp,U. Benjamin Kaupp,U. Benjamin Kaupp +19 more
TL;DR: By mass spectrometry, this work determines the copy number of nineteen chemosensory signaling proteins in sperm flagella from the sea urchin Arbacia punctulata and finds that high protein concentrations ascertain messenger detection.
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Triglyceride lipolysis triggers liquid crystalline phases in lipid droplets and alters the LD proteome
Sean Rogers,Long Gui,Anastasiia Kovalenko,Valeria Zoni,Maxime Carpentier,Kamran Ramji,Kalthoum Ben Mbarek,Amélie Bacle,Patrick Fuchs,Pablo Campomanes,Evan Reetz,Natalie Ortiz Speer,E. Reynolds,Abdou Rachid Thiam,Stefano Vanni,Daniela Nicastro,William Mike Henne +16 more
TL;DR: In situ cryo-electron tomography shows that glucose restriction triggers lipid phase transitions within LDs generating liquid crystalline lattices inside them, which alters the phase properties of LD lipids and selectively remodels the LD proteome.
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Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex.
Long Gui,Kangkang Song,Kangkang Song,Douglas Tristchler,Raqual Bower,Si Yan,Aguang Dai,Katherine Augsperger,Jason Sakizadeh,Magdalena Grzemska,Thomas W. Ni,Mary E. Porter,Daniela Nicastro +12 more
TL;DR: The overall architecture of N-DRC is revealed, with the 3 subunits DRC1/2/4 forming a core complex that serves as the scaffold for the assembly of the “functional subunits,” namely DRC3/5–8/11, and gold labeling of tagged subunits shed light on N- DRC assembly and its role in regulating flagellar beating.
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Liquid-crystalline lipid phase transitions in lipid droplets selectively remodel the LD proteome
TL;DR: Using in situ cryo-electron tomography, Wang et al. as mentioned in this paper show that glucose restriction triggers lipid phase transitions within lipid droplets, generating liquid-crystalline lattices inside them.
Glucose restriction drives spatial re-organization of mevalonate metabolism and liquid-crystalline lipid droplet biogenesis
Sean Rogers,Hanaa Hariri,Long Gui,N. Ezgi Wood,Natalie Ortiz Speer,Daniela Nicastro,W. Mike Henne +6 more
TL;DR: A non-canonical mechanism regulating mevalonate metabolism via the spatial compartmentalization of rate-limiting HMGCR enzymes is proposed, and it is revealed that AGR creates LDs with remarkable phase transition properties.