Leandro Crisostomo
University of Manitoba
8 Papers
8 Citations
Leandro Crisostomo is an academic researcher from University of Manitoba. The author has contributed to research in topics: Viral replication & Gene. The author has an hindex of 6, co-authored 8 publications.
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Papers
Clathrin mediated endocytosis is involved in the uptake of exogenous double-stranded RNA in the white mold phytopathogen Sclerotinia sclerotiorum.
Nick Wytinck,Daniel S. Sullivan,Kirsten T. Biggar,Leandro Crisostomo,Peter Pelka,Mark F. Belmonte,Steve Whyard +6 more
TL;DR: It is determined that the uptake mechanism in S. sclerotiorum occurs through clathrin-mediated endocytosis, which will prove useful in designing and optimizing future dsRNA-based control methods and in anticipating possible mechanisms by which phytopathogens may develop resistance to this novel category of fungicides.
Temporal dynamics of adenovirus 5 gene expression in normal human cells.
TL;DR: This study determined that genomes begin to replicate between 29 and 30 hours after infection, and shows that the first transcript made from viral genomes is the virus associated non-coding RNA, in particular it is detected abundant levels of virus associated RNA II fourHours after infection.
Next Generation of Tn 7-Based Single-Copy Insertion Elements for Use in Multi- and Pan-Drug-Resistant Strains of Acinetobacter baumannii
Kaleigh Ducas-Mowchun,P. Malaka De Silva,Leandro Crisostomo,Dinesh M. Fernando,Tzu-Chiao Chao,Peter Pelka,Herbert P. Schweizer,Ayush Kumar +7 more
TL;DR: This study demonstrates the practical potential of using apramycin and zeocin mini-Tn7- and Flp recombinase-encoded constructs to carry out genomic manipulations in clinical isolates of A. baumannii.
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Adenovirus 5 E1A Interacts with E4orf3 To Regulate Viral Chromatin Organization.
Andrea Michelle Soriano,Leandro Crisostomo,Megan Mendez,Drayson Graves,Jasmine Rae Frost,Oladunni Olanubi,Peter Whyte,Patrick Hearing,Peter Pelka +8 more
TL;DR: It is reported, for the first time, that E1A works together with E4orf3 to perfect the viral transcriptional program and identify a novel mechanism by which the virus can adjust viral gene expression by modifying its genome’s nucleosomal organization via cooperation between E2A and E3orf3.
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The Influence of E1A C-Terminus on Adenovirus Replicative Cycle
Leandro Crisostomo,Andrea Michelle Soriano,Jasmine Rae Frost,Oladunni Olanubi,Megan Mendez,Peter Pelka +5 more
TL;DR: This study provides the first comprehensive insight into the contributions of the C-terminus of E1A to the replicative fitness of human adenovirus 5 in arrested lung fibroblasts.
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