Lawrence Panasci
Jewish General Hospital
170 Papers
1.4K Citations
Lawrence Panasci is an academic researcher from Jewish General Hospital. The author has contributed to research in topics: DNA repair & Cancer. The author has an hindex of 42, co-authored 163 publications. Previous affiliations of Lawrence Panasci include NewYork–Presbyterian Hospital & Montreal Neurological Institute and Hospital.
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Papers
Fulvestrant 500 mg versus anastrozole 1 mg for hormone receptor-positive advanced breast cancer (FALCON): an international, randomised, double-blind, phase 3 trial.
John F.R. Robertson,Igor Bondarenko,Ekaterina Trishkina,M. Dvorkin,Lawrence Panasci,Alexey Manikhas,Yaroslav Shparyk,Servando Cardona-Huerta,Kwok-Leung Cheung,Manuel Jesus Philco-Salas,Manuel Ruiz-Borrego,Zhimin Shao,Shinzaburo Noguchi,Jacqui Rowbottom,Mary Stuart,Lynda Grinsted,Mehdi Fazal,Matthew J. Ellis +17 more
TL;DR: Fulvestrant has superior efficacy and is a preferred treatment option for patients with hormone receptor-positive locally advanced or metastatic breast cancer who have not received previous endocrine therapy compared with a third-generation aromatase inhibitor, a standard of care for first-line treatment of these patients.
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External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomised controlled trial.
Timothy J. Whelan,Jim A. Julian,Tanya Berrang,Do Hoon Kim,Isabelle Germain,Alan Nichol,Mohamed Akra,Sophie Lavertu,Francois Germain,Francois Germain,Anthony Fyles,Theresa Trotter,Francisco Perera,Susan Balkwill,Susan Chafe,Thomas McGowan,Thierry Muanza,Wayne Beckham,Boon Chua,Chu Shu Gu,Mark Levine,Ivo A. Olivotto,Carson Leong,Beverly Helen Lester,Winkle Kwan,Medhat Zikry Abd-El-Malek,Arthur Cheung,Maha Almahmudi,Joel Broomfield,Michael Sia,Melanie Reed,Jane Wilson,Islam Gharib Mohamed,Caroline Holloway,Ken I. Mills,David W. Petrik,Juanita Mary Crook,Frances Lai-Wah Wong,Hannah Mills Carolan,D. Voduc,Paris-Ann Ingledew,Sonia Nguyen,Mira Keyes,Lorna Weir,Scott Tyldesley,Peter Lim,Christina Aquino Parsons,Robert Olson,Paul Blood,Elaine Sze-Sze Wai,Pauline T. Truong,Hosam (Sam) Kader,Abraham Alexander,Aminudin Rahman Mohd Mydin,Sally Smith,Maria Vlachaki,Valerie Panet-Raymond,Krystine Lupe,Jennifer Goulart,David Nguyen,Karen Chu,Joycelin Canavan,Julianna Caon,Susan Tyler,Negin Shahid,Jacqueline Lam,John Amanie,Diane Marie Severin,Bassam Abdul Karim,Keith Tankel,Nadeem Pervez,Kurian Joseph,Zsolt Gabos,Barbara Krause,Fleur Huang,Tien Phan,Peter S. Craighead,Elizabeth Yan,J.A. (Jack) MacKinnon,Robert Nordal,Siraj Husain,Jon-Paul Voroney,Richie Sinha,James Pinilla,Andrew Cooke,Kalyani Vijayraghavan,Steven Latosinsky,Elizabeth Saettler,Yiu-Keung (James) Lau,Marianne Krahn,Ethel MacIntosh,Maged Nashed,Bashir Bashir,Vamsee Torri,Benjamin Goldenberg,Christina Kim,Vasanth Basrur,Ramana Rachakonda,Darin Gopaul,Sundeep Shahi,Sofya Kobeleva,Ian S. Dayes,D.I. Hodson,Barbara Strang,Sachi Voruganti,William McMillan,Harold I. Reiter,James G. Wright,Jonathan Sussman,Som D. Mukherjee,Susan Gudelis,David D'Souza,Michael Lock,Nancy Read,Olga Vujovic,Brian Yaremko,Edward Yu,Theodore A. Vandenberg,Jawaid Younus,Kylea Potvin,Tracy Sexton,Brian Dingle,B. Findlay,Janice Giesbrecht,Philip Hughes,Martin Samosh,Michael Levesque,Radhika Yelamanchili,Linda Lee,Rachel VanderMeer,David Wasserman,J. Bowen,David Want,Randall Bissett,Adam Andronowski,Sarwat Shehata,Hugh L. Prichard,Wayne Koll,Philip C. Chan,Jimmy Mui,Youssef M. Youssef,Holly Campbell,Medhat El-Mallah,Fawaad Iqbal,Behzad (Sayed) Banihashemi,Peter H. Dixon,Laval Grimard,Catherine Lochrin,Joanne Meng,Peter Cross,Samy El-Sayed,Bernd Esche,Paul Genest,Jean-Michel Caudrelier,Scott Morgan,Jean-Marc Bourque,Vimoj Nair,Senti Senthelal,Glenn Jones,Jonathan Tsao,John Radwan,Charles Hayter,Marisa Finlay,JD (Jidong) Lian,Yongjin Wang,Jasper Yuen,Luleul Khan,B.C. John Cho,Christine Anne Koch,Fei-Fei Liu,Lee Manchul,Michael J. McLean,Pamela Catton,Robert E. Dinniwell,Woodrow A. Wells,Wilfred Levin,Lorraine Walsh,Caroline Chung,Kathy Han,Tatiana Conrad,Joelle Helou,Aisling Barry,Ken Schneider,Khalid Hirmiz,H. Abu-Zahra,Isabelle Roy,Jose Ayllon,Pierre Del Vecchio,Marie-Andrée Fortin,Jean-Pierre Guay,Francis Methot,Pierre Rousseau,Marjory Jolicoeur,Toni Vu,Levon Igidbashian,Anne Dagnault,Luis-Victor Diaz de Bedoya,Chang Shu Wang,André Fortin,Eric Vigneault,Isabelle Vallieres,Paul-Émile Raymond,Andre-Guy Martin,Lucie Blondeau,Marie Larochelle,Nathalie Lessard,Melanie Gaudreault,Valérie Théberge,Abdenour Nabid,Olivier Ballivy,Rachel Bujold,Annie Ebacher,Sawyna Provencher,Pierre Chabot,Celine Lemaire,Peter Vavassis,Cathy Menkarios,Michael Yassa,Khalil Sultanem,Lawrence Panasci,David Melnychuk,Francois Patenaude,Wilson H. Miller,Catalin Mihalioiu,Paul Ahlgren,Richard Dalfen,Adrian Langleben,Donna Stern,Jonathan Wan,Christine Lambert,Marc David,Neil Kopek,Annie Carbonneau,Tarek Hijal,Nancy Grant,Farah Naz,M.D. Mohiuddin,S. Eshwar Kumar,Robert Rutledge,Dorianne Elizabeth Rheaume,Maureen C. Nolan,Wladyslawa Cwajna,Suki Gill,Tracie Gleisner,Solveig Grenfell,Michelle Bishop,Niluja Thiruthaneeswaran,Chen Liu,Claire Philips,Roslyn Drummond,Bronwyn King,Steven David,Mary K. Dwyer,Gillian Campbell,Susan Brooks,Ramesh Arunachalam,Giuseppe Sasso,Chelleraj Benjamin,Chakiath Jose,Christine Elder,Hedley Krawitz,Dominique Lee,Roger Huang,Sudha Purchuri,Maria Pearse,Thayavalappil Hemanth,Ruth Angell,Vikash Patel,Glenys Round,Anupam Chaudhuri,Christopher Ford +270 more
TL;DR: External beam APBI was non-inferior to whole breast irradiation in preventing ipsilateral breast tumour recurrence (IBTR), analysed by intention to treat and less acute toxicity was observed.
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Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase
TL;DR: The results demonstrate that the aggressive tumor behavior associated with a high-energy diet has similar effects on this signaling pathway and suggests a potential role for this agent in the management of a metabolically defined subset of colon cancers.
Systemic cancer therapy: achievements and challenges that lie ahead.
Michael Ostario Palumbo,Petr Kavan,Wilson H. Miller,Lawrence Panasci,Sarit Assouline,Nathalie A. Johnson,Victor Cohen,Francois Patenaude,Michael Pollak,R. Thomas Jagoe,Gerald Batist +10 more
TL;DR: This review series begins by describing some of the major advances made in systemic cancer therapy along with some of their known side-effects and makes an attempt to describe the future of systemic cancer Therapy.
Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond.
TL;DR: In this paper, the DNA-PK holoenzyme acts as a scaffold protein tethering broken DNA ends and recruiting other repair molecules, it also has enzymatic activity that may be involved in DNA damage signaling.