Laurent Jacq
6 Papers
15 Citations
Laurent Jacq is an academic researcher. The author has contributed to research in topics: Single-nucleotide polymorphism & Transmission disequilibrium test. The author has an hindex of 4, co-authored 6 publications.
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Papers
Transcriptome analysis describing new immunity and defense genes in peripheral blood mononuclear cells of rheumatoid arthritis patients.
Vitor H. Teixeira,Robert Olaso,Marie-Laure Martin-Magniette,Marie-Laure Martin-Magniette,Sandra Lasbleiz,Laurent Jacq,Catarina R. Oliveira,Pascal Hilliquin,Ivo Gut,François Cornelis,Elisabeth Petit-Teixeira +10 more
TL;DR: A remarkably elevated expression of a spectrum of genes involved in Immunity and Defense in PBMCs of RA patients compared to controls is identified, suggesting that these genes could be activated systemically in RA.
The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study
Laurent Jacq,Sophie Garnier,Philippe Dieudé,Laëtitia Michou,Céline Pierlot,Paola Migliorini,Alejandro Balsa,Rene Westhovens,Pilar Barrera,Helena Alves,Carlos Vaz,Manuela Fernandes,Dora Pascual-Salcedo,Stefano Bombardieri,Jan Dequeker,Timothy R D J Radstake,Piet L. C. M. van Riel,Leo B A van de Putte,A. Lopes-Vaz,Elodie Glikmans,Sandra Barbet,Sandra Lasbleiz,Isabelle Lemaire,Patrick Quillet,Pascal Hilliquin,Vitor H. Teixeira,Elisabeth Petit-Teixeira,Hamdi Mbarek,Bernard Prum,Thomas Bardin,François Cornélis +30 more
TL;DR: The rs3738919-C allele of the ITGAV gene is associated with RA in the European Caucasian population, suggestingITGAV as a new minor RA susceptibility gene.
•Journal Article
Genetic and expression analysis of CASP7 gene in a European Caucasian population with rheumatoid arthritis.
Vitor H. Teixeira,Laurent Jacq,Sandra Lasbleiz,Pascal Hilliquin,Catarina R. Oliveira,François Cornélis,Elisabeth Petit-Teixeira +6 more
TL;DR: CASP7 rs2227309 SNP was not associated with RA in a European Caucasian population, Nevertheless, CASP7 isoforms alpha and beta could have an involvement in the apoptosis process in RA.
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HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population
Laurent Jacq,Vitor H. Teixeira,Sophie Garnier,Laëtitia Michou,Philippe Dieudé,Dominique Rocha,Céline Pierlot,Isabelle Lemaire,Patrick Quillet,Pascal Hilliquin,Hamdi Mbarek,Elisabeth Petit-Teixeira,François Cornélis +12 more
TL;DR: It is concluded that HSPD1 is not a major RA susceptibility gene in the French Caucasian population, and three single nucleotide polymorphisms were studied in 100 RA trio families.
The MMP2 rs243865-T allele is not a major genetic factor for rheumatoid arthritis in the French Caucasian population.
TL;DR: The MMP2 rs243865‐T allele is not a major rheumatoid arthritis genetic factor in this population, and the aim was to test this allele in a French family based study.
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