Laurence John
Northwick Park Hospital
45 Papers
159 Citations
Laurence John is an academic researcher from Northwick Park Hospital. The author has contributed to research in topics: Medicine & Tuberculosis. The author has an hindex of 15, co-authored 41 publications. Previous affiliations of Laurence John include Makerere University & North-West University.
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Papers
Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings.
Graeme Meintjes,Stephen D. Lawn,Stephen D. Lawn,Fabio Scano,Gary Maartens,Martyn A. French,William Worodria,Julian Elliott,David M Murdoch,Robert J. Wilkinson,Robert J. Wilkinson,Robert J. Wilkinson,Catherine Seyler,Laurence John,Maarten F. Schim van der Loeff,Peter Reiss,Lut Lynen,Edward N. Janoff,Charles F. Gilks,Robert Colebunders,Robert Colebunders +20 more
TL;DR: In this paper, consensus case definitions for paradoxical tuberculosis-associated IRIS, ART-associated tuberculosis, and unmasking tuberculosis associated IRIS were derived, which can be used by clinicians and researchers in a variety of settings to promote standardisation and comparability of data.
•Journal Article
Tuberculosis immune reconstitution inflammatory syndrome in countries with limited resources.
TL;DR: It is important to agree on a clinical case definition of TB IRIS that could be used in resource-limited settings and would be valuable worldwide in clinical trials that are needed to answer questions on how this phenomenon could be prevented and treated.
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Drug-induced liver injury from antituberculous treatment: a retrospective study from a large TB centre in the UK
Aula Abbara,Aula Abbara,Sarah Chitty,Jennifer K. Roe,Jennifer K. Roe,Rohma Ghani,Simon M Collin,Andrew I. Ritchie,Onn Min Kon,John Dzvova,Harriet Davidson,Thomas E. Edwards,Charlotte Hateley,Matthew Routledge,Jim Buckley,Robert N. Davidson,Laurence John +16 more
TL;DR: Only a quarter of patients who developed DILI had British or American Thoracic Society defined criteria for pre-emptive LT monitoring, suggesting that all patients on ATT should be considered for universal liver monitoring particularly during the first 8 weeks of treatment.
Multidrug-resistant tuberculosis (MDR-TB) treatment in the UK: a study of injectable use and toxicity in practice
Ann Sturdy,Anna L. Goodman,Ricardo J. José,Angela Loyse,M O’Donoghue,Onn Min Kon,Martin Dedicoat,Thomas S. Harrison,Laurence John,Marc Lipman,Marc Lipman,Graham S Cooke,Graham S Cooke +12 more
TL;DR: Long-term morbidity from injectable treatment is significant even in this well-resourced setting, and the data suggest capreomycin might be associated with less ototoxicity when compared with amikacin.
Palliative care in sub-Saharan Africa
Robert Colebunders,Robert Colebunders,Robert Colebunders,Laurence John,Alex Muganzi,Lutgarde Lynen,Lutgarde Lynen,Andrew Kambugu +7 more
TL;DR: It is agreed that palliative care in the era of ART should be clearly defined and that Numerous studies have shown the effectiveness of ART in Africa.
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