Lauren E. Bufe
Harvard University
4 Papers
Lauren E. Bufe is an academic researcher from Harvard University. The author has contributed to research in topics: KRAS & Cancer. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Lauren E. Bufe include Boston University.
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Papers
CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation
Jiehui Deng,Jiehui Deng,Eric S. Wang,Russell W. Jenkins,Shuai Li,Ruben Dries,Kathleen B. Yates,Sandeep Chhabra,Wei Huang,Hongye Liu,Amir Reza Aref,Elena Ivanova,Cloud P. Paweletz,Michaela Bowden,Chensheng W. Zhou,Grit S. Herter-Sprie,Jessica A. Sorrentino,John E. Bisi,Patrick H. Lizotte,Ashley A. Merlino,Max M. Quinn,Lauren E. Bufe,Annan Yang,Yanxi Zhang,Hua Zhang,Peng Gao,Ting Chen,Megan E. Cavanaugh,Amanda J. Rode,Eric Haines,Patrick J. Roberts,Jay C. Strum,William G. Richards,Jochen H. Lorch,Sareh Parangi,Viswanath Gunda,Genevieve M. Boland,Raphael Bueno,Sangeetha Palakurthi,Gordon J. Freeman,Gordon J. Freeman,Jerome Ritz,W. Nicholas Haining,Norman E. Sharpless,Haribabu Arthanari,Geoffrey I. Shapiro,Geoffrey I. Shapiro,David A. Barbie,David A. Barbie,Nathanael S. Gray,Kwok-Kin Wong +50 more
TL;DR: It is shown that short-term exposure to small-molecule inhibitors of cyclin-dependent kinases 4 and 6 significantly enhances T- cell activation, contributing to antitumor effects in vivo, due in part to the derepression of NFAT family proteins and their target genes, critical regulators of T-cell function.
Timing of valproic acid in acute lung injury: prevention is the best therapy?
George Kasotakis,Manuel D. Galvan,Paw Osathanugrah,Neerav Dharia,Lauren E. Bufe,Zachary Breed,Joseph P. Mizgerd,Daniel G. Remick +7 more
TL;DR: A narrow therapeutic window exists in this murine model of gram-negative pneumonia-induced acute lung injury and likely explains the lack of response in studies with late administration of anti-inflammatory therapies in clinical studies.
Synergy of WEE1 and mTOR inhibition in mutant KRAS-driven lung cancers
Josephine Hai,Shengwu Liu,Lauren E. Bufe,Khanh T. Do,Ting Chen,Ting Chen,Xiaoen Wang,Christine Ng,Shuai Li,Ming-Sound Tsao,Geoffrey I. Shapiro,Kwok-Kin Wong,Kwok-Kin Wong +12 more
TL;DR: Findings demonstrate that compromised DNA repair underlies the observed potent synergy of WEE1 and mTOR inhibition and support clinical evaluation of this dual therapy for patients with KRAS-mutant lung cancers.
Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade
Esra A. Akbay,Shohei Koyama,Yan Liu,Ruben Dries,Lauren E. Bufe,Michael Silkes,Maksudul Alam,Dillon M. Magee,Robert T. Jones,Masahisa Jinushi,Meghana M. Kulkarni,Julian Carretero,Xiaoen Wang,Tiquella Warner-Hatten,Jillian D. Cavanaugh,Akio Osa,Atsushi Kumanogoh,Gordon J. Freeman,Mark M. Awad,David C. Christiani,Raphael Bueno,Peter S. Hammerman,Glenn Dranoff,Kwok-Kin Wong +23 more
TL;DR: It is shown that an increase in a single cytokine, IL‐17A, without additional mutations can promote lung cancer growth by promoting inflammation, which contributes to resistance to PD‐1 blockade and sensitizes tumors to cytokine and neutrophil depletion.