Latasha Little

TL;DR: Deep molecular profiling of melanoma patients treated with sequential checkpoint blockade demonstrated that a more clonal T cell repertoire was predictive of response to PD-1 but not CTLA-4 blockade, suggesting the potential utility of a combinatorial biomarker to optimize patient care with checkpoint blockade therapy.

TL;DR: De novo ATP1A3 mutations are identified as the primary cause ofAlternating hemiplegia of childhood and insight into disease pathophysiology is offered by expanding the spectrum of phenotypes associated with mutations in ATP 1A3.

TL;DR: Using a single-cell DNA sequencing, the clonal architecture and mutational histories of 123 acute myeloid leukemia (AML) patients are reported, revealing cell-level mutation co-occurrence and enables reconstruction ofmutational histories characterized by linear and branching patterns of clonal evolution.

TL;DR: This work employed whole-genome, whole-exome and targeted sequencing to study the somatic changes underpinning primary and secondary angiosarcoma, and identified recurrent mutations in two genes, PTPRB and PLCG1, which are intimately linked to angiogenesis.