The invention relates to a sodium bicarbonate Ringer's injection and a preparation method thereof. Effective components of each 1000ml of the sodium bicarbonate Ringer's injection comprise 5.84 g of sodium chloride, 0.30 g of potassium chloride, 0.22 g of calcium chloride dehydrate, 0.20 g of magnesium chloride hexahydrate, 2.35 g of sodium bicarbonate, citric acid and L-malic acid. The sodium bicarbonate Ringer's injection obtained by the method has good stability, is not easy to generate precipitate, has a small number of insoluble particles and is stable, and the safety of medication is greatly improved.

Sodium bicarbonate Ringer's injection and preparation method thereof

The invention provides a sodium bicarbonate Ringer injection and a preparation process. The sodium bicarbonate Ringer injection is prepared by adding sodium chloride, potassium chloride, calcium chloride hydrate, magnesium chloride, sodium bicarbonate, sodium citrate dehydrate and citric acid monohydrate to water for injection. The preparation steps comprises the steps that the prescription dosageof medicines are put into the water for injection to be stirred and dissolved, activated carbon is added, mixing and adsorption are performed, decarburization is performed, the liquid medicine is poured into a diluted preparation tank, sodium bicarbonate is added, the water for injection is supplemented to the full volume, filtering is performed, and the pH is measured; and CO2 filling is performed, and pouring, sterilization and packaging are performed. New compounding components and a compounding ratio of the sodium bicarbonate Ringer injection are provided. The invention provides a novel production and preparation process of the sodium bicarbonate Ringer injection. The production and preparation process has better sterilization effect.

Sodium bicarbonate Ringer injection and preparation process

The invention provides a sodium lactate Ringer injection production technology. The sodium lactate Ringer injection production technology comprises the processes of liquid blending, filling and sterilization, specifically, water for injection is added into a concentrated solution tank, heating is conducted, activated carbon is added for adsorption, then decarbonization is conducted, and the waterfor injection is guided into a diluted solution tank; the water for injection is added into the concentrated solution tank again, and heated, calcium chloride and potassium chloride are dissolved andthen added into the concentrated solution tank to be mixed evenly, then activated carbon is added for mixed adsorption, and then sodium chloride is added; and after decarbonization is conducted, the water for injection is added into the diluted solution tank, sodium lactate is added, and finally, finished products are filled. According to the sodium lactate Ringer injection production technology,various raw materials are dissolved and mixed better, in the stirring and mixing processes, blades and a mechanical pump are not adopted, and thus heat source substance can be prevented from enteringthe finished product more effectively.

Sodium lactate Ringer injection production technology

The invention relates to a preparation process of sodium bicarbonate Ringer's injection and an intermediate quality control method thereof. Since the preparation formula simultaneously contains Ca and HCO , CO3 is easily produced from the HCO in the preparation process, and the CO3 is further reacted with the Ca to easily produce a precipitate CaCO3, the formula is always atechnical problem of industrial production of the product for a long time. According to the technical scheme provided by the invention, the solution is prepared by a dilute preparation method, the initial addition amount and dosing sequence of water for injection before feeding sodium bicarbonate and the pH value and content of the preparation intermediate are controlled, and industrialized production of the sodium bicarbonate Ringer's injection can be effectively realized. The preparation process involved in the technical scheme is simple, convenient and feasible; and the intermediate qualitycontrol method contributes to ensuring stable and controllable quality of the finished injection, and the clinical medication safety is ensured. The invention belongs to the field of biological medicine.

Preparation process of sodium bicarbonate Ringer's injection and intermediate quality control method thereof

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Preparation process of sodium bicarbonate Ringer's injection and intermediate quality control method thereof