We acquired continuous series of microgravity measurements using several Scintrex CG-3M gravity meters for several weeks in 1997. The meters with 1 mGal resolution were installed side by side in a stable reference station at the ORSTOM research centre to perform identical data acquisition. We present and compare the instrumental responses obtained for the various gravity meters (measurement series of gravity field, standard deviation, internal temperature, tilts) and analyse their correlation with simultaneous recordings of meteorological parameters. The data have been processed in order to (1) establish the mid-to long-term relative stability and the accuracy of the instruments, (2) estimate the contribution of instrumental effects to gravity data measurements and (3) quantify the amplitude of the time variations of the gravity field that might be detected with such instruments. This study emphasizes the sensitivity of some instrumental responses of the Scintrex CG-3M gravity meters (such as internal temperature or tilt) to local atmospheric-pressure variations. This sensitivity can lead to non-negligible perturbations of the gravity measurements through automatic corrections applied in real-time mode by the integrated software. We show that most of these instrumental artefacts can be easily removed in data post-processing by using simultaneous atmospheric-pressure data. After removal of an accurate Earth tide model, the instrumental drift and the instrumental effects, the temporal series are compared by computing differential signals. These residual signals obtained over a period of several weeks exhibit the following characteristics: (1) the gravity residuals have a maximum amplitude ranging from 5 to 10 mGal and from 10 to 15 μGal for filtered and unfiltered data, respectively; and (2) the standard error, tilts and internal temperature measurements of the various gravity meters are very consistent; their respective residual amplitudes are ±2 mGal, ±3 arcsec and ±0.05 mK. In order to calibrate the gravity meters precisely in the measurement range used in this study, we have measured a calibration line established in the framework of the fourth intercomparison of absolute and relative gravity meters. This calibration was achieved with an accuracy of 5 μGal. This result is consistent with other field tests already performed with such gravity meters. In addition, we also checked the accuracy of the tilt sensors by increasing the electronic read-out by a factor of 10. The tilt response of the whole gravity meter to a small induced inclinometric variation indicates that the precision of the tilt measurements is about a few tenths of an arc second. This study reveals that temporal variations of the gravity field could potentially be detected in the field with an accuracy of about 5–15 mGal by permanent networks of Scintrex CG-3M gravity meters set up a few kilometres apart. This result is of particular interest in field surveys of temporal gravity changes related to some environmental or geodynamical processes, where the expected gravity variations are greater than a few tens of mGal. In particular, in volcanological applications, the continuous monitoring of active volcanoes with such permanent networks of gravity meters co-located with subcentimetre-accuracy GPS receivers should be very helpful to understand internal magmatic processes better and to detect possible gravity and inclinometric signals occurring during pre-eruptive phases. In this field, continuous microgravity recordings associated with classical reiteration networks will probably improve hazard mitigation in the near future

/pdf/continuous-gravity-recording-with-scintrex-cg-3m-meters-a-3qvkizuq13.pdf

Continuous gravity recording with Scintrex CG‐3M meters:a promising tool for monitoring active zones

The Sixth International Comparison of Absolute Gravimeters was held from 5 June to 28 August 2001 at the Bureau International des Poids et Mesures (BIPM), Sevres. Seventeen absolute gravimeters were used to make measurements at five sites of the BIPM gravity network. The vertical gravity gradients at the sites and the ties between them were also measured using seventeen relative gravimeters. For the first time the ties were also measured using absolute gravimeters. Various methods of processing the absolute and relative data were tested to calculate the results. The final results of ICAG-2001 are presented. The acceleration due to gravity at a height of 0.90 m is given as (980 925 701.2 ± 5.5) µGal and (980 928 018.8 ± 5.5) µGal for sites A and B, respectively, calculated using a combined adjustment of the absolute and relative data.

/pdf/results-of-the-sixth-international-comparison-of-absolute-59n96xncsv.pdf

Results of the Sixth International Comparison of Absolute Gravimeters, ICAG-2001

Like all the previous International Comparisons of Absolute Gravimeters (ICAGs) the sixth, ICAG-2001, was held at the Bureau International des Poids et Mesures (BIPM). Major improvements in the 2001 campaign were a new measurement strategy using the absolute gravimeters to measure the ties of the gravity network, new sites constructed at the BIPM, improved relative measurements of the ties and gravity gradients, and combined adjustment of the absolute and relative data, realized using new software with a novel data weighting and rejection scheme. The g-values at four sites of the BIPM were measured with an uncertainty of 6 μGal. Good agreement was obtained between the results of the absolute and relative measurements of the ties of the gravity network. The final mean gvalue obtained at the reference site A was 7 μGal less than that obtained in the previous comparison, ICAG-97.

/pdf/sixth-international-comparison-of-absolute-gravimeters-icag-3bjk1bv28d.pdf

Sixth International Comparison of Absolute Gravimeters, ICAG-2001

The 8th International Comparison of Absolute Gravimeters (ICAG-2009) and the associated Relative Gravity Campaign (RGC2009) took place at the Bureau International des Poids et Mesures (BIPM) between July and October 2009. Altogether 24 institutes with 22 absolute gravimeters and 9 relative gravimeters participated in the ICAG/RGC campaign. Accurate absolute and relative gravity measurements as well as precision levelling measurements were performed on the micro-gravity 3D-grid at the BIPM.The 2009 comparison was the first to be organized as a Comite International des Poids et Mesures (CIPM) metrological Key Comparison under the CIPM MRA (Mutual Recognition Arrangement), which means that the result will be officially recognized by the governmental organizations responsible. As a consequence, the relative gravimeters employed were carefully selected and the measurement schedules were rigorously enforced compared with earlier campaigns. Thus the quality of the RGC2009 and the determination of the BIPM local gravity network were improved.After 30 years and eight successive ICAGs, the BIPM has decided to transfer its role to the national metrological institutes, although the CIPM will continue to organize the key comparison as ICAGs. The background to the RGC2009, and the organization, data processing and final results of the gravity and vertical gravity gradients, are presented in this paper. This report is more detailed than previous final reports of the RGCs.

/pdf/relative-gravity-measurement-campaign-during-the-8th-28tc34mlof.pdf

Relative Gravity Measurement Campaign during the 8th International Comparison of Absolute Gravimeters (2009)

The fifth in the series of International Comparisons of Absolute Gravimeters (ICAG) was held at the Bureau International des Poids et Measures (BIPM) in November 1997. Fifteen absolute gravimeters participated in the comparison. The mean gravity value obtained at station A (0.9 m) at the BIPM was found to be 980 925 707.8 µGal with a standard uncertainty of 2.8 µGal. This is consistent with the results obtained in previous comparisons at this site. Conclusions based on the analysis of the present results and proposals for future activities are presented.

Results from the fifth international comparison of absolute gravimeters, ICAG'97

On the occasion of the fourth International Comparison of Absolute Gravimeters carried out at Sevres in 1994 an extensive series of microgravimetric measurements was organized. In total, fifteen LaCoste, four Scintrex CG-3M and one Sodin gravimeter measured, within a small network, vertical gravity gradients and a calibration baseline. The results show that the accuracy for single instruments is in the range of 3 μGal to 5 μGal in gravity difference, for the Scintrex and the LaCoste meters. Data from the series were also used to intercompare different ways of calibrating the gravimeter electrostatic feedback systems. The calibration platform of the Institut fur Angewandte Geodasie, (IFAG), Frankfurt, and the calibration lift of the Observatoire Royal de Belgique (ORB) were installed at Sevres and the results compared with those for the calibration line. This paper gives the first results and a review of the techniques used.

/pdf/microgravimetric-measurements-at-the-1994-international-119tsnqk2g.pdf

Microgravimetric measurements at the 1994 International Comparison of Absolute Gravimeters

The rise of antimicrobial-resistant phenotypes and the spread of the global pandemic of COVID-19 are worsening the outcomes of hospitalized patients for invasive fungal infections. Among them, candidiases are seriously worrying, especially since the currently available drug armamentarium is extremely limited. We recently reported a new class of macrocyclic amidinoureas bearing a guanidino tail as promising antifungal agents. Herein, we present the design and synthesis of a focused library of seven derivatives of macrocyclic amidinoureas, bearing a second phenyl ring fused with the core. Biological activity evaluation shows an interesting antifungal profile for some compounds, resulting to be active on a large panel of Candida spp. and C. neoformans. PAMPA experiments for representative compounds of the series revealed a low passive diffusion, suggesting a membrane-based mechanism of action or the involvement of active transport systems. Also, compounds were found not toxic at high concentrations, as assessed through MTT assays. 

https://link.springer.com/content/pdf/10.1007/s11030-022-10388-7.pdf

Focused library of phenyl-fused macrocyclic amidinoureas as antifungal agents

Our research group has been involved for a long time in the development of macrocyclic amidinoureas (MCAs) as antifungal agents. The mechanistic investigation drove us to perform an in silico target fishing study, which allowed the identification of chitinases as one of their putative targets, with 1a showing a submicromolar inhibition of Trichoderma viride chitinase. In this work, we investigated the possibility to further inhibit the corresponding human enzymes, acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1), involved in several chronic inflammatory lung diseases. Thus, we first validated the inhibitory activity of 1a against AMCase and CHIT1 and then designed and synthesized new derivatives aimed at improving the potency and selectivity against AMCase. Among them, compound 3f emerged for its activity profile along with its promising in vitro ADME properties. We also gained a good understanding of the key interactions with the target enzyme through in silico studies.

Discovery and Optimization of a Novel Macrocyclic Amidinourea Series Active as Acidic Mammalian Chitinase Inhibitors.

Microgravimetric measurements at the 1994 International Absolute Gravimeter Intercomparison in Sèvres, France

Popular Tasks used by Researchers

How can I help with your research?

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

We encountered an error while loading the panel. Please try refreshing the page.

Something went wrong

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

Anyone with the link can view this chat. You can switch it back to private anytime.

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

L. Balestri

Author Tools

Chat about Author

Papers

Microgravimetric measurements at the 1994 International Comparison of Absolute Gravimeters

Focused library of phenyl-fused macrocyclic amidinoureas as antifungal agents

Discovery and Optimization of a Novel Macrocyclic Amidinourea Series Active as Acidic Mammalian Chitinase Inhibitors.

Microgravimetric measurements at the 1994 International Absolute Gravimeter Intercomparison in Sèvres, France