Kieran James
University College Cork
13 Papers
1 Citations
Kieran James is an academic researcher from University College Cork. The author has contributed to research in topics: Bifidobacterium breve & Biology. The author has an hindex of 10, co-authored 12 publications. Previous affiliations of Kieran James include National University of Ireland.
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Papers
Maternal inheritance of bifidobacterial communities and bifidophages in infants through vertical transmission
Sabrina Duranti,Gabriele Andrea Lugli,Leonardo Mancabelli,Federica Armanini,Francesca Turroni,Kieran James,Pamela Ferretti,Valentina Gorfer,Chiara Ferrario,Christian Milani,Marta Mangifesta,Rosaria Anzalone,Moreno Zolfo,Alice Viappiani,Edoardo Pasolli,Ilaria Bariletti,Rosarita Canto,Rosanna Clementi,Marina Cologna,Tiziana Crifò,Giuseppina Cusumano,Sabina Fedi,Stefania Gottardi,Claudia Innamorati,Caterina Masè,Daniela Postai,Daniela Savoi,Massimo Soffiati,Saverio Tateo,Anna Pedrotti,Nicola Segata,Douwe van Sinderen,Marco Ventura +32 more
TL;DR: This study highlights the transmission of bifidobacterial communities from the mother to her child and implies human milk as a potential vehicle to facilitate this acquisition and represents the first example of maternal inheritance of b ifidob bacterial phages in infants following a vertical transmission route.
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Comparative genome and methylome analysis reveals restriction/modification system diversity in the gut commensal Bifidobacterium breve.
Francesca Bottacini,Ruth Morrissey,Richard J. Roberts,Kieran James,Justin van Breen,Muireann Egan,Jolanda Lambert,Kees van Limpt,Jan Knol,Mary O'Connell Motherway,Douwe van Sinderen +10 more
TL;DR: It is shown that R/M systems typically impose a very significant barrier to genetic accessibility of B. breve strains, and that cloning of a methyltransferase-encoding gene may overcome such a barrier, thus allowing future functional investigations of members of this species.
Biochemical analysis of cross-feeding behaviour between two common gut commensals when cultivated on plant-derived arabinogalactan.
TL;DR: This study advances the understanding of strain‐specific syntrophic interactions between two glycan degraders in the human gut in the presence of AG‐type dietary polysaccharides.
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Bifidobacterium breve UCC2003 Employs Multiple Transcriptional Regulators To Control Metabolism of Particular Human Milk Oligosaccharides
Kieran James,Mary O'Connell Motherway,Christophe Penno,Rebecca L. O'Brien,Douwe van Sinderen +4 more
TL;DR: A multicomponent transcriptional regulation system that controls the recently identified pathways of HMO metabolism in the infant-associated Bifidobacterium breve prototype strain UCC2003 is revealed.
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Site-Directed Mutagenesis of Bifidobacterium Strains.
Kieran James,Douwe van Sinderen +1 more
TL;DR: The use of site-directed mutagenesis is a frequently applied molecular strategy for the generation of targeted mutations, resulting in gene deletion or disruption, or alteration of their expression, thereby revealing information regarding their function.
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