Keith Burridge
University of North Carolina at Chapel Hill
195 Papers
2.9K Citations
Keith Burridge is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Focal adhesion & RHOA. The author has an hindex of 84, co-authored 195 publications. Previous affiliations of Keith Burridge include Cold Spring Harbor Laboratory.
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Papers
Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus.
Christophe Guilluy,Lukas D. Osborne,Laurianne Van Landeghem,Lisa Sharek,Richard Superfine,Rafael Garcia-Mata,Keith Burridge +6 more
TL;DR: The results demonstrate that mechanotransduction is not restricted to cell surface receptors and adhesions but can occur in the nucleus, and applying force on nesprin-1 triggers nuclear stiffening that does not involve chromatin or nuclear actin, but requires an intact nuclear lamina and emerin, a protein of the inner nuclear membrane.
The 'invisible hand': regulation of RHO GTPases by RHOGDIs.
TL;DR: The invisible hand can be used to describe the RHO-specific guanine nucleotide dissociation inhibitor (RHOGDI) family, which operates in the background, as an invisible hand, using similar forces to regulate the R HO GTPase cycle.
Recruitment of the Arp2/3 complex to vinculin: Coupling membrane protrusion to matrix adhesion
TL;DR: The recruitment of the Arp2/3 complex to vinculin may be one mechanism through which actin polymerization and membrane protrusion are coupled to integrin-mediated adhesion.
Focal adhesions, stress fibers and mechanical tension.
TL;DR: The evidence for and against the role of mechanical tension in driving the assembly of stress fibers and focal adhesions are discussed, and how their assembly is influenced by the rigidity of the substratum to which cells are adhering is considered.
390
The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins
Christophe Guilluy,Vinay Swaminathan,Rafael Garcia-Mata,E. Timothy O'Brien,Richard Superfine,Keith Burridge +5 more
TL;DR: Two guanine nucleotide exchange factors, LARG and GEF-H1, are identified as key molecules that regulate the cellular adaptation to force and stimulation of integrins with tensional force triggers activation of these two GEFs and their recruitment to adhesion complexes.
379