Keisuke Tateishi
University of Tokyo
112 Papers
905 Citations
Keisuke Tateishi is an academic researcher from University of Tokyo. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 38, co-authored 100 publications.
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Papers
Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma
Miwako Kakiuchi,Takashi Nishizawa,Hiroki R. Ueda,Kengo Gotoh,Atsushi Tanaka,Akimasa Hayashi,Shogo Yamamoto,Kenji Tatsuno,Hiroto Katoh,Yoshiaki Watanabe,Takashi Ichimura,Tetsuo Ushiku,Shin-Ichi Funahashi,Keisuke Tateishi,Ikuo Wada,Nobuyuki Shimizu,Sachiyo Nomura,Kazuhiko Koike,Yasuyuki Seto,Masashi Fukayama,Hiroyuki Aburatani,Shumpei Ishikawa +21 more
TL;DR: Comparison of mutational profiles for the major gastric cancer subtypes showed that RHOA mutations occur specifically in DGCs, the majority of which were histopathologically characterized by the presence of poorly differentiated adenocarcinomas together with more differentiated components in the gastric mucosa.
508
Correction: Corrigendum: A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion
Tsuneo Ikenoue,Yumi Terakado,Hayato Nakagawa,Yohko Hikiba,Tomoaki Fujii,Daisuke Matsubara,Rei Noguchi,Chi Zhu,Keisuke Yamamoto,Yotaro Kudo,Yoshinari Asaoka,Kiyoshi Yamaguchi,Hideaki Ijichi,Keisuke Tateishi,Noriyoshi Fukushima,Shin Maeda,Kazuhiko Koike,Yoichi Furukawa +17 more
TL;DR: Generation of the mice with liver-specific KrasG12D expression and Pten deletion and strategy to generate the compound mice are presented.
383
Loss of 5‐hydroxymethylcytosine is accompanied with malignant cellular transformation
Yotaro Kudo,Keisuke Tateishi,Keisuke Yamamoto,Shinzo Yamamoto,Yoshinari Asaoka,Hideaki Ijichi,Genta Nagae,Haruhiko Yoshida,Hiroyuki Aburatani,Kazuhiko Koike +9 more
TL;DR: The findings suggest that the amount of 5‐hmC in tumors is often reduced via various mechanisms, including the downregulation of TET1, and the critical roles of aberrant DNA demethylation for oncogenic processes in solid tissues are suggested.
298
Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
Hideaki Ijichi,Anna Chytil,Agnieszka E. Gorska,Mary Aakre,Brian Bierie,Motohisa Tada,Dai Mohri,Koji Miyabayashi,Yoshinari Asaoka,Shin Maeda,Tsuneo Ikenoue,Keisuke Tateishi,Christopher V.E. Wright,Kazuhiko Koike,Masao Omata,Harold L. Moses +15 more
TL;DR: The data indicate that tumor-stromal interactions via a Cxcr2-dependent chemokine and Ctgf axis can regulate PDAC progression and suggest that inhibiting tumor-stromal interactions might be a promising therapeutic strategy for PDAC.
Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms
Hiroki Oyama,Minoru Tada,Kaoru Takagi,Kaoru Takagi,Keisuke Tateishi,Tsuyoshi Hamada,Yousuke Nakai,Ryunosuke Hakuta,Hideaki Ijichi,Kazunaga Ishigaki,Sachiko Kanai,Hirofumi Kogure,Suguru Mizuno,Kei Saito,Tomotaka Saito,Tatsuya Sato,Tatsunori Suzuki,Naminatsu Takahara,Yasuyuki Morishita,Junichi Arita,Kiyoshi Hasegawa,Mariko Tanaka,Masashi Fukayama,Kazuhiko Koike +23 more
TL;DR: In a large long-term study of patients with branch-duct IPMNs, the 5-year incidence rate of pancreatic malignancy is found to be 3.3%, reaching 15% at 15 years after IPMN diagnosis.
211