/pdf/toxicological-profile-for-polybrominated-biphenyls-and-3sswjq38kb.pdf

Toxicological profile for polybrominated biphenyls and polybrominated diphenyl ethers

Data on Polybrominated diphenylether (PBDE) concentrations in individual U.S. women were compiled. PBDE levels in adipose tissue, serum, and breast milk from individual U.S. women were found to follow similar lognormal distributions, which exhibited a high degree of variability. The distribution of lipid-normalized PBDE concentrations for all media combined had a median of 47.9 ng/g and a 95th percentile estimate of 302 ng/g. Estimates of congener-specific kinetic parameters were used to calculate the total daily intake of the PBDEs (sum of 5 PBDE prominent congeners, PBDE-47, -99, -100, -153, and -154) that would be required to achieve the measured body burdens. PBDE intake estimates from all routes of exposure were 8.5 ng/kg/d (median) and 54 ng/kg/d (95th percentile). The potential health risks posed by the PBDEs were examined by comparing 95th percentile tissue concentrations in humans (Chuman) to modeled and measured tissue concentrations in rodents that caused no developmental neurotoxicity and reproductive effects (Crodent). The ratio of rodent-to-human PBDE concentrations (Crodent:Chuman) was <1 for alterations of male and female reproductive organs in rats, <10 for neurodevelopmental effects in mice, and <100 for neurodevelopmental effects in rats. If humans are as sensitive as animals to PBDE-induced developmental toxicity, the current margin of safety appears low for a fraction of the population.

https://setac.onlinelibrary.wiley.com/doi/pdf/10.1002/ieam.5630010404

Polybrominated diphenylether levels among united states residents: Daily intake and risk of harm to the developing brain and reproductive organs

De Toelaatbare Dagelijkse Inname (TDI) is de inname van een stof waarbij, bij levenslange blootstelling, geen nadelige effecten op de gezondheid verwacht mag worden. De afleiding van de TDI is vaak gebaseerd op de extrapolatie van bij proefdieren waargenomen toxiciteit naar de mens. Deze extrapolatie bestaat uit correcties voor verschillen in toxicokinetiek (opname, verdeling, uitscheiding) en toxicodynamie (toxisch werkingsmechanisme) tussen proefdieren en de mens Hierbij wordt er standaard vanuit gegaan dat verschillen in toxicokinetiek tussen mens en proefdier niet meer dan een factor 4 bedragen. De afleiding van de TDI voor de dioxine 2,3,7,8-TetraChloroDibenzo-p-Dioxine (TCDD) laat echter zien dat het toepassen van deze factor tot een TDI leidt die de gezondheid onvoldoende beschermt. De belangrijkste reden hiervoor is dat verschillen in de toxicokinetiek van TCDD tussen proefdier en mens veel groter zijn dan de genoemde standaardfactor. De toxicokinetiek van Persistente Organische Milieuverontreinigingen als TCDD, maar ook PolyBroom DiphenylEthers en Perfluorverbindingen, moet daarom expliciet in de afleiding van de TDI opgenomen worden. In navolging van TCDD is dit principe op tetrabroom BDE- 47 toegepast. Voor BDE-47 bleken de ontwikkeling van het centraal zenuwstelsel uitmondend in verstoorde gedragsontwikkeling en een verstoorde schildklierfunctie de gevoeligste vormen van diertoxiciteit. Wanneer met de onzekerheid bij het afleiden van de TDI rekening gehouden wordt kan op basis van deze effecten een voorlopige TDI van 7 ng/kg bw/day berekend worden.

Method for the derivation of a Human Limit Value for Brominated DiphenylEther-47

*Agency for Toxic Substances and Disease Registry. 1989. Decision guide for identifying substance-specific data needs related to toxicological profiles. Effect of polybrominated biphenyls, B-naphthoflavone and phenobarbital on arylhydrocarbon hydrolase activities and chloroform-induced nephrotoxicity and hepatotoxicity in male C57BL/6J and DBA/2J mice. Toxicology 31:343-352. An overview of commercially used brominated flame retardants, their applications, their use patterns in different countries/regions and possible modes of release. Environ Int 29:683-689.

9. References

Non-absorbable fat increases the disposal of 2,2',4,4'-tetrabromodiphenyl (BDE-47) in rats through interruption of the enterohepatic circulation

Popular Tasks used by Researchers

How can I help with your research?

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

We encountered an error while loading the panel. Please try refreshing the page.

Something went wrong

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

Anyone with the link can view this chat. You can switch it back to private anytime.

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Katarina Malmberg

Author Tools

Chat about Author

Papers

Non-absorbable fat increases the disposal of 2,2',4,4'-tetrabromodiphenyl (BDE-47) in rats through interruption of the enterohepatic circulation