K. Fichtner
5 Papers
K. Fichtner is an academic researcher. The author has contributed to research in topics: Asthma & Medicine. The author has an hindex of 3, co-authored 4 publications.
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Papers
IL-17–high asthma with features of a psoriasis immunophenotype
Jörgen Östling,Marleen van Geest,James P.R. Schofield,Zala Jevnikar,Susan J. Wilson,Jonathan Ward,René Lutter,Dominick E. Shaw,Per Bakke,Massimo Caruso,Sven-Erik Dahlén,Stephen J. Fowler,Ildiko Horvath,Norbert Krug,Paolo Montuschi,Marek Sanak,Thomas Sandström,Kai Sun,Ioannis Pandis,Charles Auffray,Ana R. Sousa,Yike Guo,Ian M. Adcock,Peter H. Howarth,Kian Fan Chung,Jeanette Bigler,Peter J. Sterk,Paul Skipp,Ratko Djukanovic,Outi Vaarala,I.M. Adcock,H. Ahmed,C. Auffray,P. Bakke,Aruna T. Bansal,F. Baribaud,Stewart Bates,E.H.D. Bel,Jeannette Bigler,Hans Bisgaard,Michael Boedigheimer,Klaus Bønnelykke,Joost Brandsma,Paul Brinkman,Enrica Bucchioni,Dominic Burg,Andrew Bush,M. Caruso,Amphun Chaiboonchoe,P. Chanez,Kian Fan Chung,Chris Compton,Julie Corfield,Anthony V. D'Amico,SE Dahlen,B. De Meulder,R. Djukanovic,Veit J. Erpenbeck,D. Erzen,K. Fichtner,Neil Fitch,Louise Fleming,Elena Formaggio,Steve J. Fowler,Urs Frey,Martina Gahlemann,Thomas Geiser,Y. Guo,Simone Hashimoto,J. Haughney,G. Hedlin,Pieter-Paul Hekking,Tim Higenbottam,Jens M. Hohlfeld,Cecile T.J. Holweg,I. Horváth,P. Howarth,Anna James,Richard G. Knowles,Alan J. Knox,N. Krug,Diane Lefaudeux,Matthew J. Loza,R. Lutter,A. Manta,Sarah Masefield,Alexander Mazein,A. Meiser,Roelinde Middelveld,M. Miralpeix,P. Montuschi,N. Mores,Clare S. Murray,Jacek Musiał,David Myles,Laurie Pahus,I. Pandis,Stelios Pavlidis,Pippa Powell,G. Praticò,M. Puig N. Rao,John H. Riley,Amanda Roberts,Graham Roberts,Anthony Rowe,T. Sandström,Wolfgang Seibold,Anna Selby,Dominic E. Shaw,Ralf Sigmund,Florian Singer,P.J. Skipp,A.R. Sousa,P. J. Sterk,K. Sun,B. Thornton,W.M. van Aalderen,M. van Geest,Jørgen Vestbo,Nadja Hawwa Vissing,Ariane H. Wagener,Scott Wagers,Z. Weiszhart,Craig E. Wheelock,S.J. Wilson,Antonios Aliprantis,David B. Allen,Kjell Alving,P. Badorrek,David Balgoma,Stephane Ballereau,Clair Barber,Manohara Kanangana Batuwitage,A. Bautmans,Alun Bedding,Annelie F. Behndig,Jorge Beleta,A. Berglind,A. Berton,Grazyna Bochenek,Armin Braun,Davide Campagna,Leon Carayannopoulos,Carmen Casaulta,Romanas Chaleckis,B. Dahlén,imothy Davison,Jorge De Alba,Inge De Lepeleire,Tamara Dekker,Ingrid Delin,Patrick Dennison,Annemiek Dijkhuis,Paul Dodson,Aleksandra Draper,K. Dyson,J. M. Edwards,L. El Hadjam,Rosalia Emma,Magnus Ericsson,C. Faulenbach,Breda Flood,Gabriella Galffy,Hector Gallart,D. Garissi,J. Gent,M. Gerhardsson de Verdier,David Gibeon,Cristina Gómez,Kerry Gove,Neil Gozzard,E. Guillmant-Farry,Elisabeth Henriksson,Lorraine Hewitt,Uruj Hoda,Richard Hu,Sile Hu,X. Hu,E. Jeyasingham,K. Johnson,N. Jullian,Juliette Kamphuis,Erika Kennington,Dyson Kerry,G. Kerry,M. Klüglich,Hugo H. Knobel,Johan Kolmert,Jon R Konradsen,Maxim Kots,Kosmas Kretsos,L. Krueger,Scott Kuo,Maciej Kupczyk,Bart N. Lambrecht,Ann-Sofie Lantz,Christopher Larminie,L. Larsson,Philipp Latzin,Nikos Lazarinis,Nathanaël Lemonnier,Saeeda Lone-Latif,L.A. Lowe,Alexander Manta,Lisa Marouzet,Jane Martin,Caroline Mathon,L. McEvoy,Sally Meah,Andrew Menzies-Gow,Leanne Metcalf,Maria Mikus,Philip Monk,Shama Naz,K. Nething,Ben Nicholas,U. Nihlén,Peter Nilsson,Robert Niven,Björn Nordlund,S. Nsubuga,Antonio Pacino,Susanna Palkonen,Johann Pellet,Giorgio Pennazza,Anne Petrén,Sandy Pink,Christophe Pison,Anthony D. Postle,Malayka Rahman-Amin,Lara Ravanetti,Emma Ray,Stacey N. Reinke,Leanne Reynolds,K. Riemann,Martine Robberechts,J.P. Rocha,Christos Rossios,Kirsty E. Russell,Michael Rutgers,G. Santini,Marco Santoninco,Mansoor Saqi,Corinna Schoelch,S. Scott,N. Sehgal,Marcus O.D. Sjödin,Barbara Smids,Caroline Smith,J.C. Smith,Katherine M. Smith,P. Söderman,A. Sogbessan,F. Spycher,Doroteya Staykova,S. Stephan,Jakob Stokholm,Karin Strandberg,M. Sunther,M. Szentkereszty,L. Tamasi,Kamran Tariq,John-Olof Thörngren,Jonathan Thorsen,Salvatore Valente,Marianne A. van de Pol,C. M. van Drunen,Jonathan Van Eyll,Jenny Versnel,Anton Vink,C. von Garnier,Aashish Vyas,Frans Wald,Samantha Walker,Kristiane Wetzel,Coen Wiegman,Siân Williams,Xian Yang,Elizabeth Yeyasingham,W. Yu Amgen,Wilhelm Zetterquist,Zaraquiza Zolkipli,A.H. Zwinderman +282 more
TL;DR: The IL-17-high asthma phenotype, characterized by bronchial epithelial dysfunction and upregulated antimicrobial and inflammatory response, resembles the immunophenotype of psoriasis, including activation of the thromboxane B2 pathway, which should be considered a biomarker for this phenotype in further studies, including clinical trials targeting IL- 17.
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Stratification of asthma phenotypes by airway proteomic signatures
James P.R. Schofield,Dominic Burg,Ben Nicholas,Fabio Strazzeri,Joost Brandsma,Doroteya Staykova,Caterina Folisi,Aruna T. Bansal,Yang Xian,Yike Guo,Anthony Rowe,Julie Corfield,Susan J. Wilson,Jonathan Ward,René Lutter,Dominick E. Shaw,Per Bakke,Massimo Caruso,Sven-Erik Dahlén,Stephen J. Fowler,Ildiko Horvath,Peter H. Howarth,Norbert Krug,Paolo Montuschi,Marek Sanak,Thomas Sandström,Kai Sun,Ioannis Pandis,John H. Riley,Charles Auffray,Bertrand De Meulder,Diane Lefaudeux,Ana R. Sousa,Ian M. Adcock,Kian Fan Chung,Peter J. Sterk,Paul Skipp,Ratko Djukanovic,H. Ahmed,David B. Allen,P. Badorrek,Stephane Ballereau,F. Baribaud,Alun Bedding,Annelie F. Behndig,A. Berglind,A. Berton,Jeanette Bigler,Michael Boedigheimer,Klaus Bønnelykke,Paul Brinkman,Andrew Bush,Davide Campagna,Carmen Casaulta,Amphun Chaiboonchoe,T. Davison,B. De Meulder,Ingrid Delin,Patrick Dennison,P. Dodson,L. El Hadjam,D. Erzen,C. Faulenbach,K. Fichtner,Neil Fitch,Elena Formaggio,Martina Gahlemann,Gabriella Galffy,D. Garissi,T. Garret,J. Gent,E. Guillmant-Farry,Elisabeth Henriksson,Uruj Hoda,Jens M. Hohlfeld,X. Hu,Alan L. James,K. Johnson,N. Jullian,G. Kerry,M. Klüglich,Richard G. Knowles,Jon R Konradsen,Kosmas Kretsos,L. Krueger,Ann-Sofie Lantz,Christopher Larminie,Philipp Latzin,D. Lefaudeux,Nathanaël Lemonnier,L.A. Lowe,R. Lutter,Alexander Manta,Alexander Mazein,L. McEvoy,Andrew Menzies-Gow,N. Mores,Clare S. Murray,K. Nething,U. Nihlén,Robert Niven,Björn Nordlund,S. Nsubuga,Johann Pellet,Christophe Pison,G. Praticò,M. Puig Valls,K. Riemann,J.P. Rocha,Christos Rossios,G. Santini,Mansoor Saqi,S. Scott,N. Sehgal,Anna Selby,P. Söderman,A. Sogbesan,F. Spycher,S. Stephan,Jakob Stokholm,M. Sunther,M. Szentkereszty,L. Tamasi,Kamran Tariq,Salvatore Valente,W.M. van Aalderen,C. M. van Drunen,J. Van Eyll,Aashish Vyas,Wen Yu,Wilhelm Zetterquist,Zaraquiza Zolkipli,A.H. Zwinderman +132 more
TL;DR: This study provides further stratification of asthma currently classified based on quantification of granulocytic inflammation and provided additional insight into their underlying mechanisms, which could become targets for novel therapies.
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Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study.
T. M. Tessa Marthe Kole,Elise Vanden Berghe,Monica Kraft,Judith M. Vonk,Martijn C. Nawijn,Salman Siddiqui,Kai Sun,Leonardo M. Fabbri,Klaus F. Rabe,Gabriele Nicolini,Christopher E. Brightling,Dave Singh,T. van der Molen,Sven-Erik Dahlén,Alvar Agusti,Rosa Faner,Jadwiga A. Wedzicha,Gavin C. Donaldson,Huib A. M. Kerstjens,Philipp Badorrek,Mariëlle E.A.C. Broeders,Wim Boersma,Alfredo Chetta,Alberto Cukier,Mike D'Amato,Ratko Djukanovic,Maria Pia Foschino,C. Gessner,Nicola A. Hanania,Raul Martin,Stefano Milleri,Ron Olivenstein,Pierluigi Paggiaro,Emilio Pizzichini,Vicente Plaza Moral,D. S. Postma,Nicola Scichilone,Robert Schilz,Antonio Spanevello,Rafael Stelmach,J. Sebastiaan Vroegop,O. Usmani,Q. Zhang,H. Ahmed,David B. Allen,Séverine Ballereau,Manohara Batuwitage,A. Bedding,Annelie F. Behndig,Anna Berglind,André Berton,Jeannette Bigler,Michael Boedigheimer,Klaus Bønnelykke,Paul Brinkman,Andrew Bush,Davide Campagna,Carmen Casaulta,Amphun Chaiboonchoe,Trevor Davison,Bertrand De Meulder,Ingrid Delin,Patrick Dennison,Paul Dodson,L. El Hadjam,D. Erzen,C. Faulenbach,K. Fichtner,Neil Fitch,Elena Formaggio,Martina Gahlemann,Gabriella Gálffy,D. Garissi,T. Garret,E. Guillmant-Farry,Elisabeth Henriksson,Uruj Hoda,JM Hohlfeld,X. Hu,Anna James,Kjetil Breivik Johnson,Nathalie Jullian,Gina Kerry,Matthias Klüglich,Richard G. Knowles,Jon R Konradsen,Kosmas Kretsos,L. Krueger,Ann-Sofie Lantz,Christopher Larminie,Philipp Latzin,Diane Lefaudeux,Nicolas Lemonnier,Lindsay A Lowe,René Lutter,Adina Manta,Alexander Mazein,L. McEvoy,Andrew Menzies-Gow,Nadia Mores,Catherine S. Murray,K Nething,Ulf Nihlén,R M Niven,Bjoern Nordlund,Saul Hannington Nsubuga,Johann Pellet,Carlos Pisón,G. Praticò,M. Puig Valls,Klaus Riemann,J.P. Rocha,Christos Rossios,Giuseppe Santini,Mária Sági,S Scott,Nitin Sehgal,A. Selby,P. O. Söderman,A.O. Sogbesan,Franziska Spycher,Schroder Stephan,Jakob Stokholm,Meera Sunther,Marton Szentkereszty,Lilla Tamási,Kamran Tariq,S. Valente,W.M.C. van Aalderen,C. M. van Drunen,Jonathan van Eyll,Akshay Vyas,W. Zetterguist,Z Zolkipli,Aeilko H. Zwinderman,Alexandre Escolà Agustí,J. Wedzicha,Robab Breyer-Kohansal,Anke-Hilse Maitland-van der Zee,Erik Melén,James P. Allinson,Lowie E.G.W. Vanfleteren,J Vestbo,Ian M. Adcock,Lies Lahousse,Maarten van den Berge,Paul Alter,F. Barbé,Marie-Kathrin Breyer,Otto C. Burghuber,Miquel Teixido Casas,Kian Fan Chung,Borja G. Cosío,Fatima Crispi,Jordi de Batlle,J. Fitting,J. Garcia,Jenny Hallberg,Sylvia Hartl,Dave West Hartford Jarvis,A. Mathioudakis,L. Nicod,Alberto Papi,Ann Ritchie,Torben Sigsgaard,Peter J. Sterk,Anja Ullman,Kilian Vellvé,C. Vogelmeier,A. Wheelock,Craig E. Wheelock +170 more
TL;DR: In this article , a post-bronchodilator FEV1/forced vital capacity (FVC) of less than the lower limit of normal at recruitment was defined in a subset of patients with asthma.
Medication Adherence in Patients With Severe Asthma Prescribed Oral Corticosteroids in the U-BIOPRED Cohort.
Fahad Alahmadi,Fahad Alahmadi,Andrew J. Simpson,Cristina Gómez,Magnus Ericsson,John-Olof Thörngren,Craig E. Wheelock,Craig E. Wheelock,Dominic E. Shaw,Louise Fleming,Graham Roberts,John H. Riley,Stewart Bates,Ana R. Sousa,Richard G. Knowles,Aruna T. Bansal,Julie Corfield,Ioannis Pandis,Kai Sun,Per Bakke,Massimo Caruso,Pascal Chanez,Barbro Dahlén,Ildiko Horvath,Norbert Krug,Paolo Montuschi,Florian Singer,Scott Wagers,Ian M. Adcock,Ratko Djukanovic,Kian Fan Chung,Peter J. Sterk,Sven-Erik Dahlén,Stephen J. Fowler,I.M. Adcock,H. Ahmed,C. Auffray,P. Bakke,A.T. Bansal,F. Baribaud,S. Bates,E.H.D. Bel,Jeanette Bigler,Hans Bisgaard,Michael Boedigheimer,Klaus Bønnelykke,Joost Brandsma,Paul Brinkman,Enrica Bucchioni,Dominic Burg,Andrew Bush,M. Caruso,Amphun Chaiboonchoe,P. Chanez,F.K. Chung,Chris Compton,J. Corfield,Anthony V. D'Amico,B. Dahlèn,S.E. Dahlén,B. De Meulder,R. Djukanovic,Veit J. Erpenbeck,D. Erzen,K. Fichtner,Neil Fitch,L.J. Fleming,Elena Formaggio,S.J. Fowler,Urs Frey,Martina Gahlemann,Thomas Geiser,Victoria M. Goss,Yike Guo,Simone Hashimoto,J. Haughney,G. Hedlin,Pieter-Paul Hekking,Tim Higenbottam,Jens M. Hohlfeld,Cecile T.J. Holweg,I. Horváth,P H Howarth,Anna James,Richard G. Knowles,Alan J. Knox,N. Krug,Diane Lefaudeux,Matthew J. Loza,René Lutter,Alexander Manta,Sarah Masefield,Jamie Matthews,Alexander Mazein,Andrea Meiser,Roelinde Middelveld,M. Miralpeix,P. Montuschi,N. Mores,Clare S. Murray,Jacek Musiał,David Myles,Laurie Pahus,I. Pandis,Stelios Pavlidis,Anthony D. Postle,P. Powel,G. Praticò,M. Puig Valls,Navin Rao,J. Riley,Amanda Roberts,G. Roberts,Anthony Rowe,Thomas Sandström,James P.R. Schofield,Wolfgang Seibold,Anna Selby,Dominick E. Shaw,Ralf Sigmund,F. Singer,Paul Skipp,A.R. Sousa,P. J. Sterk,K. Sun,B. Thornton,W.M.C. van Aalderen,M. van Geest,Jørgen Vestbo,Nadja Hawwa Vissing,Ariane H. Wagener,S.S. Wagers,Z. Weiszhart,C.E. Wheelock,Susan J. Wilson +134 more
TL;DR: Poor agreement between the two methods suggesting some disassociation between self-assessment of medication adherence and regular oral corticosteroid use is reported, which suggests that each approach may provide complementary information in clinical practice.
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Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status
Alvaro A. Cruz,John H. Riley,Aruna T. Bansal,Eduardo Vieira Ponte,Adelmir Souza-Machado,Paula Cristina Andrade Almeida,Valmar Biao-Lima,Maggie Davis,Stewart Bates,Ian M. Adcock,Peter J. Sterk,Kian Fan Chung,Neuza Maria Alcantara-Neves,P.C.A. Almeida,Leila Denise Alves Ferreira Amorim,Maria Ilma Araujo,Kathleen C. Barnes,Mauricio Lima Barreto,Emília Maria Medeiros de Andrade Belitardo,V. Bião-Lima,L. Cardoso,Paulo Augusto Moreira Camargos,José Miguel Chatkin,Ryan Santos Costa,A.C.C. Coelho,P. J. Cooper,A.A. Cruz,C.S. Cruz,J. Cunha,J.V. de Jesus,J. Fernandes,R.A. Franco,Isaac Suzart Gomes-Filho,A. Lima-Matos,Camila Alexandrina Figueiredo,M.A. Lessa,Lidia Lins,L.M. Mello,P. Moura-Santos,I.S. Muniz,I. Paixao-Araujo,G.P. Pinheiro,E.V. Ponte,Laura C. Rodrigues,C.V.N. Santana,G. Santos-Lima,T.M.O. Souza,A. Souza-Machado,Carolina Souza-Machado,Rafael Stelmach,V.S. Vasquez,I.M. Adcock,H. Ahmed,C. Auffray,Per Bakke,F. Baribaud,E.H.D. Bel,Jeanette Bigler,Hans Bisgaard,Michael Boedigheimer,Klaus Bønnelykke,Joost Brandsma,Paul Brinkman,Enrica Bucchioni,Dominic Burg,Andrew Bush,Massimo Caruso,Amphun Chaiboonchoe,P. Chanez,Chris Compton,Julie Corfield,Anthony V. D'Amico,B. Dahlén,SE Dahlen,B. De Meulder,Ratko Djukanovic,Veit J. Erpenbeck,D. Erzen,K. Fichtner,Neil Fitch,Louise Fleming,Elena Formaggio,Stephen J. Fowler,Urs Frey,Martina Gahlemann,Thomas Geiser,Victoria M. Goss,Yike Guo,Simone Hashimoto,J. Haughney,G. Hedlin,Pieter-Paul Hekking,Tim Higenbottam,Jens M. Hohlfeld,Cecile T.J. Holweg,Ildiko Horvath,P H Howarth,Anna James,Richard G. Knowles,Alan J. Knox,Norbert Krug,Diane Lefaudeux,Matthew J. Loza,René Lutter,Alexander Manta,Sarah Masefield,Jamie Matthews,Alexander Mazein,Andrea Meiser,Roelinde Middelveld,M. Miralpeix,Paolo Montuschi,N. Mores,Clare S. Murray,Jacek Musiał,David Myles,Laurie Pahus,I. Pandis,Stelios Pavlidis,Anthony D. Postle,P. Powel,G. Praticò,M. Puig Valls,Navin Rao,Amanda Roberts,Graham Roberts,Anthony Rowe,Thomas Sandström,James P.R. Schofield,Wolfgang Seibold,Anna Selby,Dominic E. Shaw,Ralf Sigmund,Florian Singer,Paul Skipp,Ana R. Sousa,P. J. Sterk,Kai Sun,B. Thornton,W.M.C. van Aalderen,M. van Geest,Jørgen Vestbo,Nadja Hawwa Vissing,Ariane H. Wagener,Scott Wagers,Z. Weiszhart,Craig E. Wheelock,S.J. Wilson +147 more
TL;DR: ProAR and U-BIOPRED cohorts, with varying severity, ethnicity and environment have similarities, which provide the basis for global external validation of asthma phenotypes, which will lead to better management.