Junyue Cao
University of Washington
40 Papers
127 Citations
Junyue Cao is an academic researcher from University of Washington. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 12, co-authored 21 publications. Previous affiliations of Junyue Cao include California Institute of Technology & Peking University.
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Papers
The single-cell transcriptional landscape of mammalian organogenesis
Junyue Cao,Malte Spielmann,Xiaojie Qiu,Xingfan Huang,Daniel M. Ibrahim,Daniel M. Ibrahim,Andrew J. Hill,Fan Zhang,Stefan Mundlos,Stefan Mundlos,Lena Christiansen,Frank J. Steemers,Cole Trapnell,Jay Shendure +13 more
TL;DR: A cell atlas of mouse organogenesis provides a global view of developmental processes occurring during this critical period, including focused analyses of the apical ectodermal ridge, limb mesenchyme and skeletal muscle.
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Comprehensive single-cell transcriptional profiling of a multicellular organism
Junyue Cao,Jonathan S. Packer,Vijay Ramani,Darren A. Cusanovich,Chau Huynh,Ray A. M. Daza,Xiaojie Qiu,Choli Lee,Scott N. Furlan,Scott N. Furlan,Scott N. Furlan,Frank J. Steemers,Andrew Adey,Andrew Adey,Robert H. Waterston,Cole Trapnell,Jay Shendure,Jay Shendure +17 more
TL;DR: The authors profiled almost 50,000 single cells from an individual Caenorhabditis elegans larval stage and were able to identify and recover information from different, even rare, cell types and develop combinatorial indexing strategies to profile the transcriptomes of single cells or nuclei.
Joint profiling of chromatin accessibility and gene expression in thousands of single cells
Junyue Cao,Darren A. Cusanovich,Vijay Ramani,Delasa Aghamirzaie,Hannah A. Pliner,Andrew J. Hill,Riza M. Daza,José L. McFaline-Figueroa,Jonathan S. Packer,Lena Christiansen,Frank J. Steemers,Andrew Adey,Andrew Adey,Cole Trapnell,Jay Shendure +14 more
TL;DR: By applying sci-CAR to lung adenocarcinoma cells and mouse kidney tissue, the authors demonstrate precision in assessing expression and genome accessibility at a genome-wide scale and provide an improvement over bulk analysis, which can be confounded by differing cellular subgroups.
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A human cell atlas of fetal gene expression
Junyue Cao,Diana R. O’Day,Hannah A. Pliner,Paul D. Kingsley,Mei Deng,Riza M. Daza,Michael Zager,Kimberly A. Aldinger,Kimberly A. Aldinger,Ronnie Blecher-Gonen,Fan Zhang,Malte Spielmann,Malte Spielmann,James Palis,Dan Doherty,Dan Doherty,Frank J. Steemers,Ian A. Glass,Ian A. Glass,Cole Trapnell,Jay Shendure +20 more
TL;DR: A pooled approach using three levels of combinatorial indexing to examine the single-cell gene expression and chromatin landscapes from 15 organs in fetal samples, which generates comprehensive atlases of early human development.
A human cell atlas of fetal chromatin accessibility
Silvia Domcke,Andrew J. Hill,Riza M. Daza,Junyue Cao,Diana R. O’Day,Hannah A. Pliner,Kimberly A. Aldinger,Kimberly A. Aldinger,Dmitry K. Pokholok,Fan Zhang,Jennifer H. Milbank,Michael Zager,Ian A. Glass,Ian A. Glass,Frank J. Steemers,Dan Doherty,Dan Doherty,Cole Trapnell,Darren A. Cusanovich,Darren A. Cusanovich,Jay Shendure +20 more
TL;DR: An improved assay using three levels of combinatorial indexing to examine the single-cell gene expression and chromatin landscapes from 15 organs in fetal samples, which identifies fetal-specific cell subtypes and nominate POU2F1 as a potential regulator of excitatory neuron development.
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