Junying Qin
Kunming Institute of Zoology
5 Papers
1 Citations
Junying Qin is an academic researcher from Kunming Institute of Zoology. The author has contributed to research in topics: Breast cancer & Transcription factor. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Junying Qin include Chinese Academy of Sciences.
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Papers
BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5.
Junying Qin,Zhongmei Zhou,Wenlin Chen,Chunyan Wang,Chunyan Wang,Chunyan Wang,Hailin Zhang,Guang-Zhe Ge,Guang-Zhe Ge,Ming Shao,Ming Shao,Dingyun You,Zhixiang Fan,Hou-Jun Xia,Rong Liu,Ceshi Chen +15 more
TL;DR: It is shown that, in breast cancer cells, KLF5 is stabilized by the deubiquitinase (DUB) BAP1, which indicates that B AP1 could be a potential therapeutic target for breast and other cancers.
Abstract 4967: The BAP1 deubiquitinase promotes triple-negative breast cancer partially by stabilizing the KLF5 transcription factor
TL;DR: A genome-wide siRNA library screening against deubiquitinases identified BAP1 as a bona fide KLF5 DUB and revealed a critical mechanism for KLf5 expression regulation in TNBC, which could be a potential therapeutic target for TNBC and other cancers.
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The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27Kip1.
Chunyan Wang,Zhi Nie,Zhongmei Zhou,Hailin Zhang,Rong Liu,Jing Wu,Jing Wu,Jing Wu,Junying Qin,Junying Qin,Ma Yun,Chen Liang,Li Shumo,Wenlin Chen,Fubing Li,Fubing Li,Peiguo Shi,Peiguo Shi,Yingying Wu,Jian Shen,Ceshi Chen +20 more
TL;DR: TEAD4 is a potential target and biomarker for the development of novel therapeutics for breast cancer and KLF5, in collaboration, promoted TNBC cell proliferation and tumor growth in part by inhibiting p27 gene transcription.
Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5)
Fei Ge,Wenlin Chen,Junying Qin,Zhongmei Zhou,Rong Liu,Lin-Lin Liu,Jing Tan,Tianning Zou,Hongyuan Li,Guosheng Ren,Ceshi Chen +10 more
TL;DR: Findings reveal a previously unrecognized role of ATXN3L in the regulation of KLF5 stability in breast cancer, and suggest it might be a therapeutic target for breast cancer.
USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5.
Yingying Wu,Yingying Wu,Yingying Wu,Junying Qin,Fubing Li,Chuanyu Yang,Zhen Li,Zhongmei Zhou,Hailin Zhang,Yunxi Li,Xinye Wang,Rong Liu,Qian Tao,Wenlin Chen,Ceshi Chen,Ceshi Chen,Ceshi Chen +16 more
TL;DR: USP3 knockdown inhibits breast cancer cell proliferation in vitro and tumorigenesis in vivo, which can be partially rescued by ectopic expression of KLF5, suggesting that USP3 may represent a potential therapeutic target for breast cancer.