Juhee Oh
University of Minnesota
21 Papers
7 Citations
Juhee Oh is an academic researcher from University of Minnesota. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 1, co-authored 2 publications.
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Papers
The influence of the blood–brain barrier in the treatment of brain tumours
Sneha R. Rathi,Jessica Griffith,Wenjuan Zhang,Wenqiu Zhang,Juhee Oh,Surabhi Talele,Jann N. Sarkaria,William F. Elmquist +7 more
TL;DR: Recognizing that the BBB represents a critical determinant of drug efficacy in central nervous system tumours will allow a more rapid translation from basic science to clinical application to develop more effective therapies.
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Central Nervous System Delivery of the Catalytic Subunit of DNA-Dependent Protein Kinase Inhibitor Peposertib as Radiosensitizer for Brain Metastases
Surabhi Talele,Wenjuan Zhang,Juhee Oh,Danielle M. Burgenske,Ann C. Mladek,Sonja Dragojevic,Jann N. Sarkaria,William F. Elmquist +7 more
TL;DR: The central nervous system distribution of peposertib, a potent catalytic subunit of DNA-dependent protein kinase inhibitor, is restricted by active efflux in the normal blood-brain barrier (BBB) but can reach significant concentrations in the tumor core.
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Overcoming translational barriers in H3K27-altered diffuse midline glioma: Increasing the drug-tumor residence time
Erica A Power,Julian S Rechberger,Liang Zhang,Juhee Oh,Jacob B. Anderson,Cody L. Nesvick,Jizhi Ge,Edward H. Hinchcliffe,William F. Elmquist,David J. Daniels +9 more
TL;DR: In this paper , a single small molecule protein kinase inhibitor with translational potential was selected for systemic and direct, loco-regional delivery to patient-derived xenografts (PDX) and genetically engineered mouse models (GEMM), and pharmacokinetic studies were conducted in non-tumor bearing rats.
Methods for intratumoral microdialysis probe targeting and validation in murine brain tumor models
Karishma Rajani,Ian Olson,Joshua J. Jacobs,Cecile Riviere-Cazaux,Kirsten Burns,Lucas P. Carlstrom,Mark A. Schroeder,Juhee Oh,Charles L. Howe,Masum Rahman,Jann N. Sarkaria,William F. Elmquist,Terry C. Burns +12 more
TL;DR: In this article, a 3D slicer-based microdialysis probe placement was used to quantify levels of extracellular onco-metabolite D-2 hydroxyglutarate in a murine intracranial tumor.
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How Much is Enough? Impact of Efflux Transporters on Drug delivery Leading to Efficacy in the Treatment of Brain Tumors.
Wenjuan Zhang,Juhee Oh,Wenqiu Zhang,Sneha R. Rathi,Jia-Chang Le,Surabhi Talele,Jann N. Sarkaria,William F. Elmquist +7 more
TL;DR: This review briefly summarizes the components and function of the normal BBB with respect to drug penetration into the brain and the alterations in the BBB due to brain tumor that could influence drug delivery.
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