Juanita Shaffer
Harvard University
28 Papers
757 Citations
Juanita Shaffer is an academic researcher from Harvard University. The author has contributed to research in topics: Transplantation & Bone marrow. The author has an hindex of 19, co-authored 28 publications.
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Papers
HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression
Tatsuo Kawai,A. Benedict Cosimi,Thomas R. Spitzer,Nina Tolkoff-Rubin,Manikkam Suthanthiran,Susan L. Saidman,Juanita Shaffer,Frederic I. Preffer,Ruchuang Ding,Vijay K. Sharma,Jay A. Fishman,Bimalangshu R. Dey,Dicken S.C. Ko,Martin Hertl,Nelson Goes,Waichi Wong,Winfred W. Williams,Robert B. Colvin,Megan Sykes,David H. Sachs +19 more
TL;DR: Five patients with end-stage renal disease received combined bone marrow and kidney transplants from HLA single-haplotype mismatched living related donors, with the use of a nonmyeloablative preparative regimen, and it was possible to discontinue all immunosuppressive therapy 9 to 14 months after the transplantation.
Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment.
Thomas Wekerle,Thomas Wekerle,Josef Kurtz,Hiroshi Ito,Joseph V. Ronquillo,Victor M. Dong,Guiling Zhao,Juanita Shaffer,Mohamed H. Sayegh,Megan Sykes +9 more
TL;DR: It is demonstrated here that treatment of naive mice with a high dose of fully major histocompatibility complex-mismatched allogeneic bone marrow, followed by one injection each of monoclonal antibody against CD154 and cytotoxic T-lymphocytes, resulted in multi-lineage hematopoietic macrochimerism that persisted for up to 34 weeks, providing the rationale for a safe approach for inducing robust transplantation tolerance in large animals and humans.
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Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies
Thomas R. Spitzer,Steven L. McAfee,Bimalangshu R. Dey,Christine Colby,J Hope,Howard Grossberg,Frederic I. Preffer,Juanita Shaffer,Stephen I. Alexander,David H. Sachs,Megan Sykes +10 more
TL;DR: Nonmyeloablative preparative therapy with MEDI-507 and haploidentical SCT have led to the reliable induction of at least transient mixed chimerism as a potential platform for adoptive cellular immunotherapy.
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Peripheral Deletion After Bone Marrow Transplantation with Costimulatory Blockade Has Features of Both Activation-Induced Cell Death and Passive Cell Death
Thomas Wekerle,Josef Kurtz,Mohamed H. Sayegh,Hiroshi Ito,Andrew D. Wells,Steven J. Bensinger,Juanita Shaffer,Laurence A. Turka,Megan Sykes +8 more
TL;DR: The deletion of donor-reactive T cells occurring early after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death, and the significance of in vitro results indicating that proteins of the Bcl family can prevent Fas-mediated apoptosis under certain circumstances is demonstrated.
Mechanisms of donor-specific tolerance in recipients of haploidentical combined bone marrow/kidney transplantation.
Giovanna Andreola,Meredith Chittenden,Juanita Shaffer,Cosimi Ab,Tatsuo Kawai,Pete Cotter,Samuel A. LoCascio,Tatsuaki Morokata,Bimalangshu R. Dey,N. T. Tolkoff-Rubin,Frederic I. Preffer,T. Bonnefoix,T. Bonnefoix,Kristin Kattleman,Thomas R. Spitzer,David H. Sachs,Megan Sykes,Megan Sykes +17 more
TL;DR: It is demonstrated that T cell recovery is gradual and is characterized by memory‐type cell predominance and an increased proportion of CD4+CD25+CD127−FOXP3+ Treg during the lymphopenic period, and long‐term tolerance appears to be maintained by a deletion or anergy mechanism.
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