Josiah B. Passmore
University of Exeter
16 Papers
Josiah B. Passmore is an academic researcher from University of Exeter. The author has contributed to research in topics: Peroxisome & Biology. The author has an hindex of 6, co-authored 10 publications. Previous affiliations of Josiah B. Passmore include Utrecht University.
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Papers
Co-regulation map of the human proteome enables identification of protein functions
Georg Kustatscher,Piotr Grabowski,Tina A. Schrader,Josiah B. Passmore,Michael Schrader,Juri Rappsilber,Juri Rappsilber +6 more
TL;DR: The machine learning algorithm treeClust was applied to reveal functional associations between co-regulated human proteins from ProteomeHD, a compilation of its own data and datasets from the Proteomics Identifications database, which produced a co-regulation map of the human proteome.
A role for Mitochondrial Rho GTPase 1 (MIRO1) in motility and membrane dynamics of peroxisomes
Inês G. Castro,David M. Richards,Jeremy Metz,Joseph L. Costello,Josiah B. Passmore,Tina A. Schrader,Ana Gouveia,Daniela Ribeiro,Michael Schrader +8 more
TL;DR: A role for Mitochondrial Rho GTPase 1 (MIRO1) is identified as an adaptor for microtubule‐dependent peroxisome motility in mammalian cells and it is demonstrated that MIRO1‐mediated pulling forces contribute to perox isome membrane elongation and proliferation in cellular models of peroxISome disease.
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The respiratory chain inhibitor rotenone affects peroxisomal dynamics via its microtubule-destabilising activity.
Josiah B. Passmore,Sónia Pinho,Maria Gomez-Lazaro,Maria Gomez-Lazaro,Michael Schrader,Michael Schrader +5 more
TL;DR: It is shown that rotenone treatment of COS-7 cells alters peroxisome morphology and distribution, but this effect is related to its microtubule-destabilising activity rather than to the generation of oxidative stress.
Intracellular redistribution of neuronal peroxisomes in response to ACBD5 expression.
Yunhong Wang,Jeremy Metz,Joseph L. Costello,Josiah B. Passmore,Michael Schrader,Christian Schultz,Markus Islinger +6 more
TL;DR: It is suggested that additional ACBD5-binding proteins in neurons may tether peroxisomes to contact sites at or near the plasma membrane of neurons, and that the VAPB-ACBD5 facilitatedperoxisome-ER interaction is not responsible for the observed organelle redistribution in neurons.
Differential roles for ACBD4 and ACBD5 in peroxisome-ER interactions and lipid metabolism.
Joseph L. Costello,Janet Koster,Beatriz S.C. Silva,Harley L. Worthy,Tina A. Schrader,Christian Hacker,Josiah B. Passmore,Frans A. Kuypers,Hans R. Waterham,Michael Schrader +9 more
TL;DR: In this paper , the role of ACBD4 and ACBD5 in peroxisome-ER contact sites was investigated using a combination of molecular cell biology, biochemical and lipidomics analyses.
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