Joseph I. Shapiro
Marshall University
335 Papers
3.5K Citations
Joseph I. Shapiro is an academic researcher from Marshall University. The author has contributed to research in topics: Medicine & Na+/K+-ATPase. The author has an hindex of 53, co-authored 317 publications. Previous affiliations of Joseph I. Shapiro include University of Colorado Boulder & West Virginia University.
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Papers
Stenting and medical therapy for atherosclerotic renal-artery stenosis
Christopher J. Cooper,Timothy P. Murphy,Donald E. Cutlip,Kenneth Jamerson,William L. Henrich,Diane M. Reid,David J. Cohen,Alan H. Matsumoto,Michael W. Steffes,Michael R. Jaff,Martin R. Prince,Eldrin F. Lewis,Katherine R. Tuttle,Joseph I. Shapiro,John H. Rundback,Joseph M. Massaro,Lance D. Dworkin +16 more
TL;DR: Renal-artery stenting did not confer a significant benefit with respect to the prevention of clinical events when added to comprehensive, multifactorial medical therapy in people with atherosclerotic renal-arterY stenosis and hypertension or chronic kidney disease.
Endogenous Cardiotonic Steroids: Physiology, Pharmacology, and Novel Therapeutic Targets
TL;DR: The physiological interactions between CTS and other regulatory systems that may be important in the pathophysiology of essential hypertension, preeclampsia, end-stage renal disease, congestive heart failure, and diabetes mellitus are focused on.
Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population.
TL;DR: A list of promising biomarkers that are associated with metabolic syndrome are compiled and this panel can aid in early detection and management of metabolic syndrome in high risk populations, such as in West Virginia.
Ouabain interaction with cardiac Na+/K+-ATPase initiates signal cascades independent of changes in intracellular Na+ and Ca2+ concentrations.
TL;DR: Ouabain-induced generation of ROS in myocytes was antagonized by genistein, a dominant negative Ras, and myxothiazol/diphenyleneiodonium, indicating a mitochondrial origin for the Ras-dependent ROS generation.
413
Intracellular Reactive Oxygen Species Mediate the Linkage of Na+/K+-ATPase to Hypertrophy and its Marker Genes in Cardiac Myocytes
TL;DR: Ouabain caused a rapid generation of ROS within the myocytes that was prevented by preexposure of cells to N-acetylcysteine (NAC) or vitamin E, and the roles of intracellular reactive oxygen species (ROS) in these ouABain-initiated pathways were explored.
345