Jørn Arnt
Lundbeck
131 Papers
2.3K Citations
Jørn Arnt is an academic researcher from Lundbeck. The author has contributed to research in topics: Agonist & Apomorphine. The author has an hindex of 45, co-authored 131 publications. Previous affiliations of Jørn Arnt include Otsuka Pharmaceutical.
Chat about Author
Papers
Pharmacological effects of a specific dopamine D-1 antagonist SCH 23390 in comparison with neuroleptics.
TL;DR: It is concluded that DA D-1 receptors are as important as D-2 receptors for the expression of neuroleptic activity in most animal models believed to be predictive of antipsychotic and extrapyramidal side-effect potential.
381
Brexpiprazole I: In vitro and in vivo characterization of a novel serotonin-dopamine activity modulator
Kenji Maeda,Haruhiko Sugino,Hitomi Akazawa,Naoki Amada,Jun Shimada,Takashi Futamura,Hiroshi Yamashita,Nobuaki Ito,Robert D. McQuade,Arne Mørk,Alan L. Pehrson,Morten Hentzer,Vibeke Nielsen,Christoffer Bundgaard,Jørn Arnt,Tine B. Stensbøl,Tetsuro Kikuchi +16 more
TL;DR: Based on a lower intrinsic activity at D2 receptors and higher binding affinities for 5-HT1A/2A receptors than aripiprazole, brexpiprazoles would have a favorable antipsychotic potential without D2 receptor agonist- and antagonist-related adverse effects.
315
Pharmacological specificity of conditioned avoidance response inhibition in rats: inhibition by neuroleptics and correlation to dopamine receptor blockade.
TL;DR: It is concluded that CAR inhibition is a sensitive test for dopamine receptor antagonists, however, additional alpha-adrenergic activity found for some neuroleptics may contribute to the CAR inhibitory potency.
268
Dopamine D-1 receptor agonists combined with the selective D-2 agonist quinpirole facilitate the expression of oral stereotyped behaviour in rats.
TL;DR: The results indicate that efficacies in the adenylate cyclase assay are dissociated from those on behaviour and indicate that in normal rats D-1 receptors are functionally relevant since D- 1 agonists facilitate the expression of oral stereotyped behaviour after combination with a D-2 agonist.
262
Biochemical effects and drug levels in rats after long-term treatment with the specific 5-HT-uptake inhibitor, citalopram.
TL;DR: Long-term treatment with citalopram does not induce changes in neurotransmitter receptors as seen with most tricyclic as well as newer “atypical” antidepressants, and the lack of β- and 5-HT2 receptor down-regulation does not seem to be a prerequisite of antidepressant activity.
167