Jörgen A. Engel
University of Gothenburg
217 Papers
4.3K Citations
Jörgen A. Engel is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Dopamine & Nucleus accumbens. The author has an hindex of 63, co-authored 216 publications.
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Papers
Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens.
Elisabet Jerlhag,Emil Egecioglu,Suzanne L. Dickson,Annika Douhan,Lennart Svensson,Jörgen A. Engel +5 more
TL;DR: Findings indicate that ghrelin might, via activation of GHSR‐1A in the VTA and LDTg, stimulate the acetylcholine–dopamine reward link, implicating that gh Relin is a part of the neurochemical overlap between the reward systems and those that regulate energy balance.
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Requirement of central ghrelin signaling for alcohol reward
Elisabet Jerlhag,Emil Egecioglu,Sara Landgren,Nicolas Salomé,Markus Heilig,Diederik Moechars,Rakesh Datta,Daniel Perrissoud,Suzanne L. Dickson,Jörgen A. Engel +9 more
TL;DR: Central ghrelin signaling, via GHS-R1A, not only stimulates the reward system, but is also required for stimulation of that system by alcohol.
413
Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models.
TL;DR: The results suggest that NPY exerts anxiolytic-like effects, and that these effects are mediated through an interaction with noradrenergic systems.
391
Ghrelin Increases Intake of Rewarding Food in Rodents
Emil Egecioglu,Elisabet Jerlhag,Nicolas Salomé,Karolina P. Skibicka,David Haage,Mohammad Bohlooly-Y,Daniel Andersson,Mikael Bjursell,Daniel Perrissoud,Jörgen A. Engel,Suzanne L. Dickson +10 more
TL;DR: This article investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food.
Voluntary ethanol intake in the rat: effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment
TL;DR: The present results further implicate central nicotinic receptors in the molecular events mediating the reinforcing properties of ethanol, and suggest that subchronic nicotine enhances the responsiveness of mesolimbic dopamine neurons both to nicotine and to ethanol.
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