Jonathan Green

TL;DR: An innate, heading-neuron-dependent, tethered navigational behavior where walking flies maintain a straight trajectory along a specific angular bearing for hundreds of body lengths is established.

TL;DR: PESCA, a scalable and generalizable method that leverages ATAC- and single-cell RNA-sequencing protocols, is developed to characterize cell-type-specific enhancers that should enable genetic access and perturbation of gene function across mammalian cell types, and is demonstrated to have significant implications for both basic and translational research.

TL;DR: It is found that silencing a large but genetically defined set of non-motor neurons virtually eliminates spontaneous flight turns while preserving the tethered flies' ability to perform two types of visually evoked turns, demonstrating that, at least in flies, these two modes of action are almost completely dissociable.

TL;DR: This work identifies a molecularly defined subset of somatostatin-positive inhibitory neurons in the mouse posterior parietal cortex that carries a cell-type-specific error-correction signal for navigation and proposes that this subtype of Sst neurons provides a self-reinforcing and cell-type-specific error-correction signal in the posterior parietal cortex that may help with the execution and learning of accurate goal-directed navigation trajectories.