Jon Kerry
University of Oxford
16 Papers
47 Citations
Jon Kerry is an academic researcher from University of Oxford. The author has contributed to research in topics: Regulation of gene expression & Enhancer. The author has an hindex of 9, co-authored 16 publications. Previous affiliations of Jon Kerry include Medical Research Council.
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Papers
RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction.
Adam C. Wilkinson,Erica Ballabio,Huimin Geng,Huimin Geng,Phillip North,Marta Tapia,Jon Kerry,Debabrata Biswas,Robert G. Roeder,C. David Allis,Ari Melnick,Marella F. T. R. de Bruijn,Thomas A. Milne +12 more
TL;DR: A mechanism of transformation whereby two oncogenic fusion proteins cooperate by activating a target gene and then modulating the function of its downstream product is highlighted.
156
MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.
Juliana Benito,Laura Godfrey,Kensuke Kojima,Leah Hogdal,Mark Wunderlich,Huimin Geng,Isabel Marzo,Karine Harutyunyan,Leonard S. Golfman,Phillip North,Jon Kerry,Erica Ballabio,Triona Ni Chonghaile,Oscar Gonzalo,Yihua Qiu,Irmela Jeremias,La Kiesha Debose,Eric O'Brien,Helen Ma,Ping Zhou,Rodrigo Jacamo,Eugene Park,Kevin R. Coombes,Nianxiang Zhang,Deborah A. Thomas,Susan O'Brien,Hagop M. Kantarjian,Joel D. Leverson,Steven M. Kornblau,Michael Andreeff,Markus Müschen,Patrick A. Zweidler-McKay,James C. Mulloy,Anthony Letai,Thomas A. Milne,Marina Konopleva +35 more
TL;DR: It is shown that t(4;11) patient cells express high levels of BCL-2 and are highly sensitive to treatment with the BCL -2-specific BH3 mimetic ABT-199, and it is demonstrated that MLL/AF4 specifically upregulates the Bcl-2 gene but not other B CL-2 family members via DOT1L-mediated H3K79me2/3.
143
Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia.
Shan Lin,Roger T. Luo,Anetta Ptasinska,Jon Kerry,Salam A. Assi,Mark Wunderlich,Toshihiko Imamura,Joseph J. Kaberlein,Ahmad Rayes,Mark J Althoff,John Anastasi,Maureen M. O'Brien,Amom Ruhikanta Meetei,Thomas A. Milne,Constanze Bonifer,James C. Mulloy,Michael J. Thirman +16 more
TL;DR: It is shown that MLL fused to murine Af4, highly conserved with human AF4, produces high-titer retrovirus permitting efficient transduction of human CD34+ cells, thereby generating a model of t(4;11) pro-B acute lymphoblastic leukemia (ALL) that fully recapitulates the immunophenotypic and molecular aspects of the disease.
115
Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia
Sachith Mettananda,Sachith Mettananda,Chris Fisher,Deborah Hay,Mohsin Badat,Lynn Quek,Kevin Clark,Philip Hublitz,Damien J. Downes,Jon Kerry,M Gosden,Jelena Telenius,Jackie Sloane-Stanley,Paula Faustino,Paula Faustino,Andreia Coelho,Jessica Doondeea,Batchimeg Usukhbayar,Paul Sopp,Jacqueline A. Sharpe,Jim R. Hughes,Paresh Vyas,Paresh Vyas,Richard J. Gibbons,Douglas R. Higgs,Douglas R. Higgs +25 more
TL;DR: It is shown that a proportion of the edited CD34+ cells are long-term repopulating hematopoietic stem cells, demonstrating the potential of this approach for translation into a therapy for β-thalassemia.
109
Dynamics of the 4D genome during in vivo lineage specification and differentiation.
A M Oudelaar,Robert A. Beagrie,M Gosden,S de Ornellas,E Georgiades,Jon Kerry,Daniel Hidalgo,Joana Carrelha,Arun Shivalingam,Afaf H. El-Sagheer,Afaf H. El-Sagheer,Jelena Telenius,Tom Brown,Veronica J. Buckle,Merav Socolovsky,Douglas R. Higgs,Jim R. Hughes +16 more
TL;DR: Tiled-C, a low-input 3C approach to study genome architecture at high resolution, is applied to mouse erythroid differentiation in vivo, finding that enhancer-promoter interactions are formed gradually during differentiation, concomitant with progressive upregulation of gene activity.