John S. Lazo
University of Virginia
55 Papers
306 Citations
John S. Lazo is an academic researcher from University of Virginia. The author has contributed to research in topics: Cancer & Cell culture. The author has an hindex of 21, co-authored 55 publications. Previous affiliations of John S. Lazo include University of Pittsburgh & Discovery Institute.
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Papers
Drugging Undruggable Molecular Cancer Targets
TL;DR: The basis for the undruggable moniker is outlined, a reclassification of these targets as undrugged targets is proposed, and three general classes of this imposing group are highlighted as exemplars with some attendant strategies currently being explored to reclassify them.
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Identifying Actives from HTS Data Sets Practical Approaches for the Selection of an Appropriate HTS Data-Processing Method and Quality Control Review
TL;DR: The authors developed a 3-step statistical decision methodology to determine the most appropriate HTS data-processing method and establish criteria for quality control review and active identification from 3-day assay signal window and DMSO validation tests.
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Auranofin Is an Apoptosis-Simulating Agent with in Vitro and in Vivo Anti-leishmanial Activity
Elizabeth R. Sharlow,Stephanie Leimgruber,Samantha Murray,Ana Lira,Richard J. Sciotti,Mark Hickman,Thomas H. Hudson,Susan E. Leed,Diana Caridha,Amy M. Barrios,David A Close,Max Grogl,John S. Lazo +12 more
TL;DR: An integrated in vitro and in vivo screening platform that incorporated multiple Leishmania life cycles and species and probed a focused library of pharmaceutically active compounds identified the Food and Drug Administration-approved drug auranofin as a potent cytotoxic anti-leishmanial agent and inducer of apoptotic-like death in promastigotes.
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Protein-tyrosine Phosphatase 4A3 (PTP4A3) Promotes Vascular Endothelial Growth Factor Signaling and Enables Endothelial Cell Motility
Mark W. Zimmerman,Kelley E. McQueeney,Jeffrey S. Isenberg,Bruce R. Pitt,Karla A. Wasserloos,Gregg E. Homanics,John S. Lazo,John S. Lazo +7 more
TL;DR: Findings support a role for PTP4A3 as an important contributor to endothelial cell function and as a multimodal target for cancer therapy and mitigating VEGF-regulated angiogenesis.
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Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion.
Yan Wang,John S. Lazo +1 more
TL;DR: The results support a model in which PRL-2 promotes cell migration and invasion through an ERK-dependent signaling pathway and no significant changes were found in total p53, Akt and c-Src expression levels or their phosphorylation status.
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