John J. Pacella
University of Pittsburgh
82 Papers
303 Citations
John J. Pacella is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 16, co-authored 51 publications. Previous affiliations of John J. Pacella include Drexel University.
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Papers
Myocardial ischemic memory imaging with molecular echocardiography
Flordeliza S. Villanueva,Erxiong Lu,Shivani Bowry,Sevgi Kilic,Eric M. Tom,Jianjun Wang,Joan Gretton,John J. Pacella,William R. Wagner +8 more
TL;DR: Echocardiographic identification of recently ischemic myocardium is possible using ultrasound contrast agents targeted to selectins and may offer a new approach to the more timely and precise diagnosis of acute coronary syndrome in patients presenting with chest pain of uncertain cardiac origin.
169
Endovascular Ultrasound Renal Denervation to Treat Hypertension: The RADIANCE II Randomized Clinical Trial.
Michel Azizi,Manish Saxena,Yale Wang,J. Stephen Jenkins,Chandan Devireddy,Florian Rader,Naomi D.L. Fisher,Roland E. Schmieder,Felix Mahfoud,Jason B. Lindsey,Kintur Sanghvi,Thomas M. Todoran,John J. Pacella,John M. Flack,Joost Daemen,Andrew S.P. Sharp,Philipp Lurz,Michael J. Bloch,Michael A. Weber,Mel Lobo,Jan Basile,Lisa Claude,Helen Reeve-Stoffer,Candace K. McClure,Ajay J. Kirtane +24 more
TL;DR: In this paper , two initial sham-controlled trials demonstrated that ultrasound renal denervation decreases blood pressure (BP) in patients with mild to moderate hypertension and hypertension that is resistant to treatment.
104
Effect of Acoustic Conditions on Microbubble-Mediated Microvascular Sonothrombolysis
Jonathan E. Leeman,Jong S. Kim,Francois T.H. Yu,Xucai Chen,Kang Kim,Jianjun Wang,Xianghui Chen,Flordeliza S. Villanueva,John J. Pacella +8 more
TL;DR: This model uniquely provides a means to systematically evaluate multiple acoustic and microbubble parameters for the optimization of microvascular sonothrombolysis and may obviate the need for adjunctive rt-PA and could have important clinical cost and safety benefits.
73
New insights into mechanisms of sonothrombolysis using ultra-high-speed imaging.
TL;DR: Observations suggest that a direct mechanical effect of oscillating lipid microbubbles on an adjacent thrombus may play a role in mediating clot disruption in the presence of specific ultrasound conditions.
72
Fluid Viscosity Affects the Fragmentation and Inertial Cavitation Threshold of Lipid-Encapsulated Microbubbles.
TL;DR: The propensity for individual microbubble fragmentation was found to significantly decrease in 4-cP fluid compared with 1- cP fluid, despite achieving similar maximum radial excursions, and in vitro studies should consider an evaluation using physiologic viscosity perfusate before transitioning to in vivo evaluations.