John Connelly
Imperial College London
13 Papers
322 Citations
John Connelly is an academic researcher from Imperial College London. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 10, co-authored 10 publications.
Chat about Author
Papers
Metabonomics: a platform for studying drug toxicity and gene function
TL;DR: Metabonomics is a systems approach for studying in vivo metabolic profiles, which promises to provide information on drug toxicity, disease processes and gene function at several stages in the discovery-and-development process.
1.9K
Integrated Metabonomic Analysis of the Multiorgan Effects of Hydrazine Toxicity in the Rat
Sarah Garrod,Mary E. Bollard,Andrew W. Nicholls,Susan C. Connor,John Connelly,Jeremy K. Nicholson,Elaine Holmes +6 more
TL;DR: Alanine levels were observed in all tissues indicative of a general inhibition of alanine transaminase activity and NMR spectral profiles of treated rats appeared similar to those of matched controls for all tissue types indicative of recovery from toxic insult.
497
Chemometric models for toxicity classification based on NMR spectra of biofluids
Elaine Holmes,Andrew W. Nicholls,John C. Lindon,Susan C. Connor,John Connelly,John N. Haselden,Stephen J. P. Damment,Manfred Spraul,Peter Neidig,Jeremy K. Nicholson +9 more
TL;DR: Chemometric analysis of the control urine spectra indicated that HW rat urine contained relatively higher concentrations of lactate, acetate, and taurine and lower concentrations of hippurate than SD rat urine, which will enable on-line toxicological assessment of biofluids and will provide a tool for probing the mechanistic basis of organ toxicity.
301
Development of a model for classification of toxin-induced lesions using 1H NMR spectroscopy of urine combined with pattern recognition.
Elaine Holmes,Andrew W. Nicholls,John C. Lindon,S. Ramos,Manfred Spraul,Peter Neidig,Susan C. Connor,John Connelly,S. J. P. Damment,J. Haselden,Jeremy K. Nicholson +10 more
TL;DR: Pattern recognition approaches were developed and applied to the classification of 600 MHz 1H NMR spectra of urine from rats dosed with compounds that induced organ‐specific damage in either the liver or kidney, confirming the robust nature of the derived model.
241
An integrated proteomic approach to studying glomerular nephrotoxicity.
Paul Cutler,David J. Bell,Helen C. Birrell,John Connelly,Susan C. Connor,Elaine Holmes,Bob C. Mitchell,Soraya Y. Monté,Bill A. Neville,Russell Pickford,Steven Polley,Klaus Schneider,J. Mark Skehel +12 more
TL;DR: Urinary high performance liquid chromatography profiles and high resolution proton nuclear magnetic resonance spectroscopy has been utilised to simultaneously detect toxin‐induced changes in the relative concentrations of a number of metabolites, and the proteomic approach has the potential to provide significantly more mechanistic information than is provided readily by traditional clinical chemistry.
68