Jingyun Yang
Sichuan University
20 Papers
Jingyun Yang is an academic researcher from Sichuan University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications.
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Papers
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity.
Jingyun Yang,Wei Wang,Zimin Chen,Shuaiyao Lu,Fanli Yang,Zhenfei Bi,Linlin Bao,Fei Mo,Xue Li,Yong Huang,Weiqi Hong,Yun Yang,Yuan Zhao,Fei Ye,Sheng Lin,Wei Deng,Hua Chen,Hong Lei,Ziqi Zhang,Min Luo,Hong Gao,Yue Zheng,Yanqiu Gong,Xiaohua Jiang,Yanfeng Xu,Qi Lv,Dan Li,Manni Wang,Fengdi Li,Shunyi Wang,Guanpeng Wang,Pin Yu,Yajin Qu,Li Yang,Hongxin Deng,Aiping Tong,Jiong Li,Z. H. Wang,Jinliang Yang,Guobo Shen,Zhiwei Zhao,Yuhua Li,Jingwen Luo,Hongqi Liu,Wenhai Yu,Mengli Yang,Jingwen Xu,Junbin Wang,Haiyan Li,Haixuan Wang,Dexuan Kuang,Panpan Lin,Zhengtao Hu,Wei Guo,Wei Cheng,Yanlin He,Xiangrong Song,Chong Chen,Zhihong Xue,Shaohua Yao,Lu Chen,Xuelei Ma,Siyuan Chen,Maling Gou,Weijin Huang,Youchun Wang,Changfa Fan,Zhixin Tian,Ming Shi,Fu-Sheng Wang,Lunzhi Dai,Min Wu,Gen Li,Guangyu Wang,Yong Peng,Zhiyong Qian,Canhua Huang,Johnson Y.N. Lau,Zhenglin Yang,Yuquan Wei,Xiaobo Cen,Xiaozhong Peng,Chuan Qin,Kang Zhang,Guangwen Lu,Xiawei Wei +85 more
TL;DR: It is shown that a recombinant vaccine that comprises residues 319–545 of the RBD of the spike protein induces a potent functional antibody response in immunized mice, rabbits and non-human primates as early as 7 or 14 days after the injection of a single vaccine dose.
A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant
Cai He,Jingyun Yang,Weiqi Hong,Zimin Chen,Dandan Peng,Hong Lei,Aqu Alu,Xuemei He,Zhenfei Bi,Xiaohua Jiang,Guowen Jia,Yun jeong Yang,Yanan Zhou,Wenhai Yu,Cong Tang,Q. Huang,Mengli Yang,Baijun Li,Jingmei Li,Junbin Wang,H. Que,Li Chen,Wen Ren,Dandan Wan,Jiong Li,Wei Wang,Guobo Shen,Zhi Wei Zhao,Li Jun Yang,Jinliang Yang,Zhenling Wang,Zhaoming Su,Yuquan Wei,Xiaobo Cen,Yoshimasa Tanaka,Shuaiyao Lu,Xiaozhong Peng,Guangwen Lu,Xiawei Wei +38 more
TL;DR: Wang et al. as mentioned in this paper developed a subunit vaccine named RBD-HR/trimer by directly linking the sequence of RBD derived from the Delta variant (containing L452R and T478K) and HR1 and HR2 in SARS-CoV-2 S2 subunit in a tandem manner.
Spike protein of SARS‐CoV‐2 Omicron (B.1.1.529) variant has a reduced ability to induce the immune response
Cai He,Xuemei He,Jingyun Yang,Hong Lei,Weiqi Hong,Li Jun Yang,Jiong Li,Wei Wang,Guobo Shen,Guangwen Lu,Xiawei Wei +10 more
TL;DR: Omicron variant harbors >30 substitutions/deletions/insertions in the spike, including 15 substitutions in receptor-binding domain (RBD) according to GISAID, the dominant preva-lence of Omicron and faster transmissibility than Delta variant.
Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants
Hong Lei,Aqu Alu,Jingyun Yang,Wen Ren,Cai He,Tianxia Lan,Xuemei He,Li Jun Yang,Jiong Li,Zhenling Wang,Wei Wang,Guangwen Lu,Xiawei Wei +12 more
TL;DR: In this paper , an adjuvanted intranasal RBD vaccine was developed and monitored its long-term immunogenicity against both wild-type and mutant strains of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), including Omicron variants, in mice.
Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection
Jingyun Yang,Weiqi Hong,Hong Lei,Cai He,W. Lei,Yanan Zhou,Tingmei Zhao,Aqu Alu,Xu-Kai Ma,Jiong Li,Li Yang,Zhenling Wang,Wei Wang,Guangwen Lu,Guobo Shen,Shuaiyao Lu,Guizhen Wu,Huashan Shi,Xiawei Wei +18 more
TL;DR: In Chengdu, China, an infection wave was predominantly induced by the BA.5 infection wave, and evaluated the neutralization against pseudoviruses as discussed by the authors , showing that convalescent sera from individuals, regardless of vaccination history, had remarkably compromised neutralization capacities against the newly emerged XBB and XBB.1.5 subvariants.