Jill Skepner
GlaxoSmithKline
7 Papers
29 Citations
Jill Skepner is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Interleukin 17 & Cellular differentiation. The author has an hindex of 5, co-authored 7 publications.
Chat about Author
Papers
Targeting Th17 cells in autoimmune diseases.
TL;DR: The rationale for targeting two checkpoints in the development and inflammatory function of Th17 cells, retinoid-related orphan receptor-γt (RORγt) and IL-23, and the development of both RORγt small molecule inhibitors andIL-23 neutralizing antibodies is discussed.
341
Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo.
Jill Skepner,Radha Ramesh,Mark Trocha,Darby Schmidt,Erkan Baloglu,Mercedes Lobera,Thaddeus J. Carlson,Jonathan Hill,Lisa A. Orband-Miller,Ashley A. Barnes,Mohamed Boudjelal,Mark S. Sundrud,Shomir Ghosh,Jianfei Yang +13 more
TL;DR: It is demonstrated that RORγt inverse agonists inhibit Tc17 cell differentiation, as well as IL-17 production by γδ T cells and CD8+ T c17 cells, and block imiquimod-induced cutaneous inflammation.
In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists
Jill Skepner,Mark Trocha,Radha Ramesh,Xiaoyan Qu,Darby Schmidt,Erkan Baloglu,Mercedes Lobera,Scott Davis,Michael A. Nolan,Thaddeus J. Carlson,Jonathan Hill,Shomir Ghosh,Mark S. Sundrud,Mark S. Sundrud,Jianfei Yang +14 more
TL;DR: It is shown that the RORγt inverse agonist TMP778 acts potently and selectively to block mouse Th 17 cell differentiation in vitro and to impair Th17 cell development in vivo upon immunization with the myelin antigen MOG35–55 plus complete Freund's adjuvant.
19
Small molecule inhibitors targeting the Th17 cell transcription factor RORγt for the treatment of autoimmune diseases
TL;DR: Naive CD4+ T helper cells can differentiate into Th1, Th2, Th17, T regulatory, Th9 and Th22 cells, which are shown to play a critical role in a variety of autoimmune diseases including rheumatoid arthritis, multiple sclerosis, psoriasis, inflammatory bowel disease (IBD), and asthma.
10
In vivo regulation of gene expression and Th17 differentiation by RORγt inverse agonists.
Jill Skepner,Mark Trocha,Radha Ramesh,Xiaoyan Qu,Darby Schmidt,Erkan Baloglu,Mercedes Lobera,Scott Davis,Michael A. Nolan,Thaddeus J. Carlson,Jonathan Hill,Shomir Ghosh,Mark S. Sundrud,Jianfei Yang +13 more
- 01 Jan 2015
3