Jiena Wu
Southern Medical University
21 Papers
13 Citations
Jiena Wu is an academic researcher from Southern Medical University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 7 publications.
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Papers
Smp24, a Scorpion-Venom Peptide, Exhibits Potent Antitumor Effects against Hepatoma HepG2 Cells via Multi-Mechanisms In Vivo and In Vitro
Tienthanh Nguyen,Ruiyin Guo,Jinwei Chai,Jiena Wu,Junfang Liu,Xin Chen,Mohamed A. Abdel-Rahman,Hu Xia,Xueqing Xu +8 more
TL;DR: The data suggest that the antitumor effect of Smp24 is closely related to the induction of cell apoptosis, cycle arrest, and autophagy via cell membrane disruption and mitochondrial dysfunction, suggesting a potential alternative in hepatocellular carcinoma treatment.
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The Strong Anti-Tumor Effect of Smp24 in Lung Adenocarcinoma A549 Cells Depends on Its Induction of Mitochondrial Dysfunctions and ROS Accumulation
Ruiyin Guo,Xuewen Chen,Tienthanh Nguyen,Jinwei Chai,Yahua Gao,Jiena Wu,Jinqi Li,Mohamed A. Abdel-Rahman,Xin Chen,Xueqing Xu +9 more
TL;DR: The antitumor effect of Smp24 against A549 cells is related to the induction of apoptosis, autophagy plus cell cycle arrest via mitochondrial dysfunction, and ROS accumulation.
FM-CATH, A Novel Cathelicidin From Fejervarya Multistriata, Shows Therapeutic Potential for Treatment of CLP-Induced Sepsis
Jiena Wu,Haiyun Zhang,Xiaoxin Chen,Jinwei Chai,Yunrui Hu,Weichen Xiong,Wancheng Lu,Maolin Tian,Xin Chen,Xueqing Xu +9 more
TL;DR: In this paper, a novel cathelicidin, FM-CATH, from the frog skin of F. multistriata was found to adopt an amphipathic α-helix structural in membrane-mimetic environments and possess favorable antimicrobial effects against bacteria and fungus.
Tablysin-15 inhibits osteoclastogenesis and LPS-induced bone loss via attenuating the integrin αvβ3 pathway
TL;DR: The results indicate that Tablysin-15 significantly suppresses osteoclastogenesis in vitro and in vivo, thus it might be a excellent candidate for treating osteolytic-related diseases.
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Fejerlectin, a Lectin-like Peptide from the Skin of Fejervarya limnocharis, Inhibits HIV-1 Entry by Targeting Gp41.
Weichen Xiong,Chenliang Zhou,Shuwen Yin,Shuwen Yin,Jinwei Chai,Baishuang Zeng,Jiena Wu,Yi-Bin Li,Lin Li,Xueqing Xu +9 more
- 24 Feb 2021
TL;DR: In this paper, the authors characterized a lectin-like peptide, fejerlectin (RLCYMVLPCP), isolated from the skin of the frog Fejervarya limnocharis, which showed significant hemagglutination and d-(+)-galacturonic acid-binding activities.
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