A random scan system comprising a dispersion pre-compensation unit (1), a random scan unit (2), and an imaging unit (3). The dispersion pre-compensation unit (1) is configured to perform dispersion pre-compensation and optical path adjustment on incident light to enable the incident light to reach the random scan unit (2) perpendicularly, thereby implementing scanning of any region. The random scan unit (2) is further configured to collect fluorescent signals generated after the scanning of any region, and process the fluorescent signals and then enable same to reach the imaging unit (3) for imaging. The use of dual acousto-optic deflector based scanning technology avoids a mechanical offset of galvanometer scanning, and provides high scanning precision and a fast scanning speed. In addition, the acousto-optic deflector based scanning technology can further implement quick selection, scanning and imaging of a region of interest, greatly reduce photodamage while ensuring the resolution unchanged, and cause almost no photodamage in a region of non-interest in a field of view.

Random scan system

Two-photon microscope has become an important instrument in neuroscience research.However,the current commercial instruments can hardly meet the need for the detection of neural signal in millisecond scale due to their low imaging rates.Fast random-access two-photon microscopy based on acousto-optic deflector(AOD) has the potential for increasing the observation speed while maintaining adequate signal to noise ratio(SNR).We summarize the latest related research progress.It is demonstrated from four parts,including the spatio-temporal evolution theory of the femtosecond laser after passing the angular dispersion devices,dispersion compensation method for AOD,random-access two-photon microscopy instrument,and calcium signal identification method in the instrument applications.In the end,the future development trends for random-access two-photon microscopy are discussed.The systematic and in-deep research on this technology will provide a new tool for the neural activity observation and boost the development of brain science.

Random-access Two-photon Microscopy for Neural Activity Observation

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Random-access Two-photon Microscopy for Neural Activity Observation