Fasting serum triglycerides, free fatty acids, and malondialdehyde are increased in preeclampsia, are positively correlated, and decrease within 48 hours post partum ☆ ☆☆ ★ ★★

Placental lipid peroxides and thromboxane are increased and prostacyclin is decreased in women with preeclampsia

Therapeutic potential of vitamin E in the pathogenesis of spontaneous atherosclerosis.

Deficient glutathione peroxidase activity in preeclampsia is associated with increased placental production of thromboxane and lipid peroxides

Neuropathy, mechanical stress, and macrovascular disease are involved in the pathogenesis of diabetic foot ulceration. Implicit in the development of gangrene and ulceration is the recognition that these factors interact with the microcirculation, resulting in the failure of skin capillary flow to meet nutritive requirements. There is little evidence to associate structural microangiopathy with foot microcirculatory failure. Significant functional abnormalities of the microcirculation have been defined. In accord with the haemodynamic hypothesis early hyperaemia and capillary hypertension promote more sinister late functional abnormalities with increasing duration of diabetes. These late functional abnormalities include loss of autoregulation and reduced hyperaemic responses which interact with loss of neurogenic flow regulation, disturbed endothelial function, and abnormal rheology to produce the familiar clinical picture of the diabetic foot. Ischaemia secondary to multi-segment arterial disease induces additional abnormalities of microcirculatory function which are superimposed on the pre-existing diabetic microvascular structural and functional microangiopathy.

Aetiology of diabetic foot ulceration: a role for the microcirculation?

Effect of hyperlipidemic serum on lipid peroxidation, synthesis of prostacyclin and thromboxane by cultured endothelial cells: protective effect of antioxidants.

Effects of lipid peroxides on prostacyclin and thromboxane generation in hypercholesterolemic rabbits.

Lipid peroxides, glutathione peroxidase, prostacyclin and cell cycle stages in normal and atherosclerotic Japanese quail arteries

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Effect of hyperlipidemic serum on lipid peroxidation, synthesis of prostacyclin and thromboxane by cultured endothelial cells: protective effect of antioxidants.

Effects of lipid peroxides on prostacyclin and thromboxane generation in hypercholesterolemic rabbits.

Lipid peroxides, glutathione peroxidase, prostacyclin and cell cycle stages in normal and atherosclerotic Japanese quail arteries