Jiagen Wen
Central South University
13 Papers
17 Citations
Jiagen Wen is an academic researcher from Central South University. The author has contributed to research in topics: Medicine & Nephrotoxicity. The author has an hindex of 7, co-authored 12 publications.
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Papers
Rs495828 polymorphism of the ABO gene is a predictor of enalapril-induced cough in Chinese patients with essential hypertension.
Jian-Quan Luo,Fa-Zhong He,Zhiying Luo,Jiagen Wen,Lu-Yan Wang,Ning-Ling Sun,Gen-Fu Tang,Qing Li,Dong Guo,Zhao-Qian Liu,Hong-Hao Zhou,Xiao-Ping Chen,Wei Zhang +12 more
TL;DR: The rs495828 polymorphism was associated with enalapril-induced cough and may serve as a useful pharmacogenomics marker of the safety of enalAPril in Chinese patients with essential hypertension.
44
Aging increases the susceptibility of cisplatin-induced nephrotoxicity.
Jiagen Wen,Mei-Zi Zeng,Yan Shu,Dong Guo,Yi Sun,Zhen Guo,Youhong Wang,Zhao-Qian Liu,Hong-Hao Zhou,Wei Zhang +9 more
TL;DR: Age increased the susceptibility of CDDP-induced renal function decline or nephrotoxicity, and the induced alterations of TNF-α, ICAM-1, and TLR4 were more extensive in old mice.
Effect of NR3C2 genetic polymorphisms on the blood pressure response to enalapril treatment.
Jian-Quan Luo,Lu-Yan Wang,Fa-Zhong He,Ning-Ling Sun,Gen-Fu Tang,Jiagen Wen,Zhiying Luo,Zhao-Qian Liu,Hong-Hao Zhou,Xiao-Ping Chen,Wei Zhang +10 more
TL;DR: NR3C2 rs5522 affects blood pressure response to enalapril treatment and may serve as a useful pharmacogenomic marker of antihypertensive response to EnAlapril in essential hypertension patients.
23
Cadmium exposure enhances organic cation transporter 2 trafficking to the kidney membrane and exacerbates cisplatin nephrotoxicity.
Hong Yang,Jie Tang,Dong Guo,Qingqing Zhao,Jiagen Wen,Yanjuan Zhang,Obinna N. Obianom,Shiwei Zhou,Wei Zhang,Yan Shu +9 more
TL;DR: It is reported that cadmium exposure significantly increased the activity of organic cation transporter 2 (OCT2), a critical renal drug transporter recommended in United States Federal Drug Administration guidance for assessment during drug development.
16
The RGS2 (-391, C>G) genetic variation correlates to antihypertensive drug responses in Chinese patients with essential hypertension.
Fa-Zhong He,Jian-Quan Luo,Zhitao Zhang,Zhiying Luo,Lan Fan,Yijing He,Jiagen Wen,Dingilang Zhu,Jinping Gao,Yan Wang,Yuesheng Qian,Hong-Hao Zhou,Xiao-Ping Chen,Wei Zhang +13 more
TL;DR: The RGS2 (-391, C>G) genetic polymorphism may serve as a biomarker to predict a patient’s response to antihypertensive drug therapy, but future studies need to confirm this.