Jean P. Hubble
Ohio State University
62 Papers
951 Citations
Jean P. Hubble is an academic researcher from Ohio State University. The author has contributed to research in topics: Essential tremor & Levodopa. The author has an hindex of 38, co-authored 62 publications. Previous affiliations of Jean P. Hubble include Novartis.
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Papers
A controlled trial of rasagiline in early Parkinson disease: The tempo study
Andrew Siderowf,Matthew B. Stern,Ira Shoulson,Karl Kieburtz,David Oakes,Denni Day,Aileen Shinaman,Sandra Plumb,Stanley Fahn,Karen Blindauer,Mark F. Lew,Howard I. Hurtig,Mary Lloyd,Robert A. Hauser,Lisa Gauger,Lawrence I. Golbe,Joanne Wojcieszek,Joann Belden,Andrew Feigin,Mary Lou Klimek,Barbara Shannon,William G. Ondo,Christine Hunter,Vincent Calabrese,Paul Atchison,Cathy W. Allen,Frederick J. Marshall,Debra Berry,Irenita Gardiner,Janis M. Miyasaki,Luisa Del Rizzo,Tilak Mendis,Neila Mendis,Peggy Gray,Jean P. Hubble,Karen Betcher,Rajesh Pahwa,Eric Molho,Diane Brown,Lisa M. Shulman,Ali H. Rajput,Marianne Ewanishin,Mark Stacy,Kelli Williamson,John M. Bertoni,Carolyn Peterson,Paul J. Tuite,Brenda Ebbitt,Kathleen M. Shannon,Jean A. Jaglin,Caroline M. Tanner,Kenneth Marek,Karen Stavris,Michael J. Aminoff,Mariann DiMinno,Glenna A. Dowling,Un Jung Kang,Judy Richman,Kapil D. Sethi,W.R. Wayne Martin,Pamela King,Germaine McInnes,Charles H. Adler,Peter A. LeWitt,Maryan DeAngelis,Myrna Schear,Mark Forrest Gordon,Roberta Winnick,Robert G. Feldman,Cathi A. Thomas,Kelly M. Conn,Alicia Brocht,Chris Chadwick,Jeannette Connolly,Susan Daigneault,Shirley Eberly,Janice Bausch,Lee Josephson,Rosemary Oliva,Steven R. Schwid,Anthony E. Lang,Christopher Cox,Carrie Irvine,John G. Nutt,William B. White,Sheila Oren,Ruth Levy,Eli Eyal,David Ladkani,Wayne Houck +89 more
TL;DR: Rasagiline is effective as monotherapy for patients with early PD and the 2 dosages in this trial were both effective relative to placebo.
High‐frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor
William C. Koller,Rajesh Pahwa,Karen Busenbark,Jean P. Hubble,Steve Wilkinson,Anthony E. Lang,Paul J. Tuite,Elspeth Sime,Lazano A,Robert A. Hauser,Teresita Malapira,Donald A. Smith,Daniel Tarsy,Miyawaki E,Thorkild Norregaard,Kormos T,C. W. Olanow +16 more
TL;DR: Chronic high‐frequency stimulation of the ventral intermedius nucleus of the thalamus is safe and highly effective in ameliorating essential and parkinsonian tremor and measures of function were significantly improved in patients with essential tremor.
511
Long-term evaluation of deep brain stimulation of the thalamus.
Rajesh Pahwa,Kelly E. Lyons,Steven B. Wilkinson,Richard K. Simpson,William G. Ondo,Daniel Tarsy,Thorkild Norregaard,Jean P. Hubble,Donald A. Smith,Robert A. Hauser,Joseph Jankovic +10 more
TL;DR: Thalamic stimulation is safe and effective for the long-term management of essential and Parkinsonian tremors and Bilateral stimulation can cause dysarthria and incoordination and should be used cautiously.
399
Randomized trial of the adenosine A2A receptor antagonist istradefylline in advanced PD
TL;DR: Istradefylline was generally well tolerated and reduced “off” time as assessed by home diaries, and nausea was the most common adverse event.
318
Complete genomic screen in Parkinson disease: evidence for multiple genes.
William K. Scott,Martha Nance,Ray L. Watts,Jean P. Hubble,William C. Koller,Kelly E. Lyons,Rajesh Pahwa,Matthew B. Stern,Amy Colcher,Bradley C. Hiner,Joseph Jankovic,William G. Ondo,Fred H. Allen,Christopher G. Goetz,Gary W. Small,Donna Masterman,Frank L. Mastaglia,Nigel G. Laing,Jeffrey M. Stajich,Brandon D. Slotterbeck,Michael W. Booze,Robert C. Ribble,Evadnie Rampersaud,Sandra G. West,Rachel A. Gibson,Lefkos T. Middleton,Allen D. Roses,Jonathan L. Haines,Burton L. Scott,Jeffery M. Vance,Margaret A. Pericak-Vance +30 more
TL;DR: The data suggest that the parkin gene is important in early-onset PD and that multiple genetic factors may be important in the development of idiopathic late-ONSet PD.
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