Jamie B. Cote

TL;DR: The acid mediated cyclization of a protected N -acylhydroxyguanidine into the corresponding 3-amino-1,2,4-oxadiazole and confirmation of its structure by single crystal X-ray crystallography is reported in this article.

TL;DR: The authors concerne des composes et des compositions desdits composes ainsi que des procedes d'utilisation de composes pour traiter des affections ophtalmiques associees a localisation incorrecte de proteines d'opsine, le repliement incorrect de proteine d'opine mutantes and la production de produits du cycle visuel toxiques qui s'accumulent dans l'œil.

TL;DR: An optimized synthetic route to prepare ring-locked retinoid 1a has been developed and it is found that isomerically pure 1a can be stored in amber vials under argon at −20°C for use over time (up to six months) without degradation, enabling 1a to be an accessible and valuable biological tool.