33 Papers
270 Citations
Isabel Veiga is an academic researcher from Institute of Molecular Pathology and Immunology of the University of Porto. The author has contributed to research in topics: Germline mutation & Microsatellite instability. The author has an hindex of 18, co-authored 31 publications.
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Papers
Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status
Carla Oliveira,Jantine L. Westra,Diego Arango,Miina Ollikainen,Enric Domingo,Ana Ferreira,Sérgia Velho,Renee C. Niessen,Kristina Lagerstedt,Pia Alhopuro,Päivi Laiho,Isabel Veiga,Manuel R. Teixeira,Marjolijn J. L. Ligtenberg,Jan H. Kleibeuker,Rolf H. Sijmons,John T. M. Plukker,Kohzoh Imai,Pedro Lage,Richard Hamelin,Cristina Albuquerque,Simó Schwartz,Annika Lindblom,Päivi Peltomäki,Hiroyuki Yamamoto,Lauri A. Aaltonen,Raquel Seruca,Robert M.W. Hofstra +27 more
TL;DR: It is shown that depending on the genetic/epigenetic mechanism leading to MSI-H, the outcome in terms of oncogenic activation may be different, reinforcing the idea that HNPCC, sporadic MSI-h (depending on the hMLH1 status) and MSS CRCs, may target distinct kinases within the RAS/RAF/MAPK pathway.
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E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients
Carla Oliveira,Paulo Ferreira,Sérgio Nabais,Luisa Campos,Ana Ferreira,Luis Cirnes,Catarina Castro Alves,Isabel Veiga,Maria Fragoso,Fernando Regateiro,Luís Dias,Herculano Moreira,Gianpaolo Suriano,José Carlos Machado,José Carlos Machado,Carlos Lopes,Sérgio Castedo,Sérgio Castedo,Fátima Carneiro,Fátima Carneiro,Raquel Seruca,Raquel Seruca +21 more
TL;DR: The present work highlights the need for p53 mutation screening in families lacking CDH1 germline mutations, in a country with one of the highest incidences of gastric cancer in the world.
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POLE somatic mutations in advanced colorectal cancer.
Joana Guerra,Carla M. A. Pinto,Diana Pinto,Manuela Pinheiro,Romina Silva,Ana Peixoto,Patrícia Rocha,Isabel Veiga,Catarina Santos,Rui Santos,Verónica Cabreira,Paula Lopes,Rui Henrique,Manuel R. Teixeira +13 more
TL;DR: It is concluded that POLE somatic mutations exist but are rare in advanced CRC, with further larger studies being necessary to evaluate its biological and clinical implications.
High resolution melting analysis of KRAS, BRAF and PIK3CA in KRAS exon 2 wild-type metastatic colorectal cancer
Joana G. Guedes,Isabel Veiga,Patrícia Rocha,Pedro Contreiras Pinto,Carla M. A. Pinto,Manuela Pinheiro,Ana Peixoto,Maria Candida Barisson Villares Fragoso,A. Raimundo,Paula M. T. Ferreira,Manuela Machado,N. Sousa,Paula Lopes,António Araújo,Joana Espiga Macedo,Fernando Alves,Camila Coutinho,Rui Henrique,Lúcio Lara Santos,Manuel R. Teixeira +19 more
TL;DR: About one fourth of mCRC cases wild-type for KRAS codons 12 and 13 present other mutations either in KRAS, BRAF, or PIK3CA, many of which may explain the lack of response to anti-EGFR therapy observed in a significant proportion of these patients.
Mutations in exon 14 of dihydropyrimidine dehydrogenase and 5-Fluorouracil toxicity in Portuguese colorectal cancer patients
Natália Salgueiro,Isabel Veiga,Maria Candida Barisson Villares Fragoso,Olga Sousa,Nuno Almeida Costa,Maria L Pellon,Evaristo Sanches,José Guimarães dos santos,Manuel R. Teixeira,Sérgio Castedo +9 more
TL;DR: It is concluded that mutations in exon 14 of DPYD gene are responsible for a significant proportion of life-threatening toxicity to 5-Fluorouracil, and should therefore be excluded before its administration to cancer patients.
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