Ingo Thomsen
University of Kiel
12 Papers
20 Citations
Ingo Thomsen is an academic researcher from University of Kiel. The author has contributed to research in topics: Primary sclerosing cholangitis & Genome-wide association study. The author has an hindex of 8, co-authored 11 publications. Previous affiliations of Ingo Thomsen include Brigham and Women's Hospital.
Chat about Author
Papers
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Jimmy Z. Liu,Johannes R. Hov,Trine Folseraas,Trine Folseraas,Eva Ellinghaus,Simon M. Rushbrook,Nadezhda Tsankova Doncheva,Ole A. Andreassen,Ole A. Andreassen,Rinse K. Weersma,Tobias J. Weismüller,Bertus Eksteen,Pietro Invernizzi,Gideon M. Hirschfield,Gideon M. Hirschfield,Daniel Gotthardt,Albert Parés,David Ellinghaus,Tejas Shah,Brian D. Juran,Piotr Milkiewicz,Christian Rust,Christoph Schramm,Tobias Müller,Brijesh Srivastava,Georgios N. Dalekos,Markus M. Nöthen,Stefan Herms,Juliane Winkelmann,Mitja Mitrovic,Felix Braun,Cyriel Y. Ponsioen,Peter J. P. Croucher,Martina Sterneck,Andreas Teufel,Andrew Mason,Janna Saarela,Virpi Leppa,Ruslan Dorfman,Domenico Alvaro,Annarosa Floreani,Suna Onengut-Gumuscu,Stephen S. Rich,Wesley K. Thompson,Andrew J. Schork,Sigrid Næss,Sigrid Næss,Ingo Thomsen,Gabriele Mayr,Inke R. König,Kristian Hveem,Isabelle Cleynen,Isabelle Cleynen,Javier Gutierrez-Achury,Isis Ricaño-Ponce,David A. van Heel,Einar Björnsson,Richard Sandford,Peter R. Durie,Espen Melum,Espen Melum,Morten H. Vatn,Morten H. Vatn,Morten H. Vatn,Mark S. Silverberg,Richard H. Duerr,Leonid Padyukov,Stephan Brand,Miquel Sans,Vito Annese,Jean-Paul Achkar,Jean-Paul Achkar,Kirsten Muri Boberg,Kirsten Muri Boberg,Hanns-Ulrich Marschall,Olivier Chazouillères,Christopher L. Bowlus,Cisca Wijmenga,Erik Schrumpf,Erik Schrumpf,Severine Vermeire,Mario Albrecht,John D. Rioux,John D. Rioux,Graeme J.M. Alexander,Annika Bergquist,Judy H. Cho,Stefan Schreiber,Michael P. Manns,Martti Färkkilä,Anders M. Dale,Roger W. Chapman,Konstantinos N. Lazaridis,Andre Franke,Carl A. Anderson,Tom H. Karlsen +95 more
TL;DR: This analysis compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip to identify 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16.
High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis
Philippe Goyette,Gabrielle Boucher,Dermot Mallon,Eva Ellinghaus,Luke Jostins,Luke Jostins,Hailiang Huang,Stephan Ripke,Elena S. Gusareva,Vito Annese,Stephen L. Hauser,Jorge R. Oksenberg,Ingo Thomsen,Stephen Leslie,Mark J. Daly,Kristel Van Steen,Richard H. Duerr,Jeffrey C. Barrett,Dermot P.B. McGovern,L. Philip Schumm,James A. Traherne,Mary N Carrington,Vasilis Kosmoliaptsis,Tom H. Karlsen,Tom H. Karlsen,Andre Franke,John D. Rioux +26 more
TL;DR: High-density SNP typing of the MHC in >32,000 individuals with IBD implicates multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis, suggesting an important role of the adaptive immune response in the colonic environment in the pathogenesis of IBD.
Whole genome and exome sequencing of monozygotic twins discordant for Crohn’s disease
Britt-Sabina Petersen,Martina E. Spehlmann,Andreas Raedler,Bjoern Stade,Ingo Thomsen,Raquel Rabionet,Philip Rosenstiel,Stefan Schreiber,Andre Franke +8 more
TL;DR: This study constitutes the first to perform whole genome sequencing for CD twins and therefore provides a valuable reference dataset for future studies and presents an example framework for mosaicism detection and point to the challenges in these types of analyses.
SNP discovery performance of two second-generation sequencing platforms in the NOD2 gene region.
Espen Melum,Sandra May,Markus Schilhabel,Ingo Thomsen,Tom H. Karlsen,Philip Rosenstiel,Stefan Schreiber,Andre Franke +7 more
TL;DR: The Crohn's disease (CD)‐associated NOD2 gene was subjected to targeted resequencing using two different second‐generation sequencing technologies and SNP detection performance fell rapidly when the achieved coverage was below 40×.
GrabBlur - a framework to facilitate the secure exchange of whole-exome and -genome SNV data using VCF files
TL;DR: GrabBlur is a newly developed tool to aggregate and share NGS-derived single nucleotide variant (SNV) data in a public database, keeping individual samples unidentifiable, so that it is impossible to reconstruct complete exomes or genomes from the database or to re-identify single individuals.