Imogen Elsum
Burnet Institute
18 Papers
12 Citations
Imogen Elsum is an academic researcher from Burnet Institute. The author has contributed to research in topics: Biology & SCRIB. The author has an hindex of 9, co-authored 15 publications. Previous affiliations of Imogen Elsum include University of Melbourne & Peter MacCallum Cancer Centre.
Chat about Author
Papers
Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module.
Patrick O. Humbert,Nicola A. Grzeschik,Anthony M. Brumby,Ryan C. Galea,Imogen Elsum,Helena E. Richardson +5 more
TL;DR: The evidence for the involvement of Scribble, Dlg, and Lgl in cancer, and how the various functions ascribed to these tumour suppressors in Drosophila and mammalian systems may impact on the process of tumourigenesis are reviewed.
340
SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia
Helen B. Pearson,Pedro A. Perez-Mancera,Lukas E. Dow,Andrew Ryan,Pierre Tennstedt,Debora Bogani,Imogen Elsum,Andy Greenfield,David A. Tuveson,Ronald Simon,Patrick O. Humbert +10 more
TL;DR: It is reported that Scrib is indispensable for prostate homeostasis in mice and Mechanistically, Scrib was shown to negatively regulate the MAPK cascade to suppress tumorigenesis, suggesting that the polarity network could provide a new avenue for therapeutic intervention.
Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling
Lukas E. Dow,Lukas E. Dow,Imogen Elsum,C L King,Kathryn M. Kinross,Helena E. Richardson,Patrick O. Humbert +6 more
TL;DR: It is shown that in human epithelial cells expressing oncogenic Ras or Raf, loss of Scribble promotes invasion of cells through extracellular matrix in an organotypic culture system and the mechanism by which this occurs is in the regulation of MAPK signalling by Scribble.
High Levels of Transmitted HIV Drug Resistance in a Study in Papua New Guinea.
Evelyn Lavu,Ellan Kave,Euodia Mosoro,Jessica Markby,Eman Aleksic,Janet Gare,Janet Gare,Imogen Elsum,Gideon Nano,Petronia Kaima,Nick Dala,Anup Gurung,Silvia Bertagnolio,Suzanne M. Crowe,Mark Myatt,Anna C. Hearps,Michael R. Jordan +16 more
TL;DR: The level of transmitted HIV drug resistance in antiretroviral drug naïve individuals recently infected with HIV in Port Moresby is amongst the highest reported globally and threatens to limit the on-going effective use of NNRTIs as a component of first-line ART in Papua New Guinea.
A community-based co-designed genetic health service model for Aboriginal Australians
Imogen Elsum,Libby Massey,Callum McEwan,Desiree LaGrappe,Emma Kowal,Ravi Savarirayan,Gareth Baynam,Misty R. Jenkins,Gail Garvey,Margaret Kelaher +9 more
TL;DR: The MJDF model takes a community-based, person-and family-centred approach to successfully deliver effective specialist genetic health services in remote community settings and it is proposed that these approaches have broad application in the future design and delivery of specialist health services particularly in culturally complex settings.