Ian M. McDonald
University of North Carolina at Chapel Hill
8 Papers
Ian M. McDonald is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Chemistry & Kinase. The author has an hindex of 5, co-authored 7 publications.
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Papers
Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues
Paul R. Graves,Lucas J. Aponte-Collazo,Emily M.J. Fennell,Adam C. Graves,Andrew E. Hale,Nedyalka Dicheva,Laura E. Herring,Thomas S. K. Gilbert,Michael P. East,Ian M. McDonald,Matthew R. Lockett,Hani Ashamalla,Nathaniel J. Moorman,Donald S. Karanewsky,Edwin J. Iwanowicz,Ekhson Holmuhamedov,Lee M. Graves +16 more
TL;DR: It is reported that ClpP directly binds ONC201 and the related TR compounds and is an important biological target for this class of molecules.
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Kinome Profiling Identifies Druggable Targets for Novel Human Cytomegalovirus (HCMV) Antivirals.
Kyle C. Arend,Erik M. Lenarcic,Heather A. Vincent,Naim U. Rashid,Eric Lazear,Ian M. McDonald,Thomas S. K. Gilbert,Michael P. East,Laura E. Herring,Gary L. Johnson,Lee M. Graves,Nathaniel J. Moorman +11 more
TL;DR: Results show the utility of MIB-MS kinome profiling for identifying existing kinase inhibitors that can potentially be repurposed as novel antiviral drugs.
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Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth.
Linas J. Krulikas,Ian M. McDonald,Benjamin Lee,Denis O. Okumu,Michael P. East,Thomas S. K. Gilbert,Laura E. Herring,Brian T. Golitz,Carrow I. Wells,Allison D. Axtman,William J. Zuercher,Timothy M. Willson,Dmitri Kireev,Jen Jen Yeh,Gary L. Johnson,Antonio T. Baines,Lee M. Graves +16 more
- 09 May 2018
TL;DR: A coordinated approach to discover novel kinase inhibitors, evaluate their efficacy in 3D models, and define their specificity against the kinome is described.
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Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells.
Ian M. McDonald,Gavin D. Grant,Michael P. East,Thomas S. K. Gilbert,Emily M. Wilkerson,Dennis Goldfarb,Joshua Beri,Laura E. Herring,Cyrus Vaziri,Jeanette Gowen Cook,Michael J. Emanuele,Lee M. Graves +11 more
TL;DR: It is observed that MELK inhibition delays mitotic entry, likely via transient G2/M checkpoint activation, and this results provide a rationale for using 8a as a tool compound for functional studies of M ELK.
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Measuring Kinase Activity-A Global Challenge.
TL;DR: This review will discuss many of the current and developing methods for studying kinase activity, and evaluate their applications, advantages, and disadvantages.
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