Hongping Chen
Thomas Jefferson University
18 Papers
37 Citations
Hongping Chen is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Hongping Chen include University of Modena and Reggio Emilia.
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Papers
Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer
Hansjuerg Alder,Cristian Taccioli,Cristian Taccioli,Hongping Chen,Yubao Jiang,Karl J. Smalley,Paolo Fadda,Hatice Gulcin Ozer,Kay Huebner,John L. Farber,Carlo M. Croce,Louise Y.Y. Fong +11 more
TL;DR: The finding that ZD causesmiR-31 and miR-21 dysregulation associated with inflammation provides insight into mechanisms whereby ZD promotes ESCC.
Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression
Shaogui Wan,Cristian Taccioli,Yubao Jiang,Hongping Chen,Karl J. Smalley,Kun Huang,Xiuping Liu,John L. Farber,Carlo M. Croce,Louise Y.Y. Fong +9 more
TL;DR: ZD activates alternative inflammation‐associated cancer pathways that fuel tumor progression and bypass the antitumor effect of Cox‐2 ablation, which has important clinical implications, as combination cancer therapy that includes Zn may improve efficacy.
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Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo.
Cristian Taccioli,Michela Garofalo,Hongping Chen,Yubao Jiang,Guidantonio Malagoli Tagliazucchi,Gianpiero Di Leva,Hansjuerg Alder,Paolo Fadda,Justin Middleton,Karl J. Smalley,Tommaso Selmi,Srivatsava Naidu,John L. Farber,Carlo M. Croce,Louise Y.Y. Fong +14 more
TL;DR: The data define the in vivo signaling pathway underlying interaction of Zn deficiency and miR-31 overexpression in esophageal neoplasia and provide a mechanistic rationale for mi R-31 as a therapeutic target for ESCC.
Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats.
Louise Y.Y. Fong,Ruiyan Jing,Karl J. Smalley,Zi-Xuan Wang,Cristian Taccioli,Sili Fan,Hongping Chen,Hansjuerg Alder,Kay Huebner,John L. Farber,Oliver Fiehn,Oliver Fiehn,Carlo M. Croce +12 more
TL;DR: The discovery that the Zn-depleted middle-aged rat prostate has a metabolic phenotype resembling that of human prostate cancer, with a 10-fold down-regulation of citric acid, links citrate reduction directly to prostatic Zn loss, providing the underlying mechanism linking dietary Zn deficiency with miR-183-96-182 overexpression.
Zinc Finger Proteins: Functions and Mechanisms in Colon Cancer
TL;DR: A comprehensive understanding of the action mechanisms of ZFPs in colon cancer will not only shed light on the discovery of new diagnostic and prognosis indicators but will also facilitate the design of novel targeted therapies.