Hong-Bin Sun
China Pharmaceutical University
11 Papers
21 Citations
Hong-Bin Sun is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: Medicine & Hippocampal formation. The author has an hindex of 7, co-authored 11 publications.
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Papers
Montelukast ameliorates streptozotocin-induced cognitive impairment and neurotoxicity in mice
Chun Teng Zhang,Jing Ran Lin,Feng Wu,Arijit Ghosh,Su Su Tang,Mei Hu,Yan Long,Hong-Bin Sun,Hao Hong +8 more
TL;DR: Results suggest that montelukast improves memory impairment and inhibits neuroinflammation and apoptosis in mice exposed to STZ, and may provide a novel strategy for treating or preventing AD.
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RAGE-NF-κB-PPARγ Signaling is Involved in AGEs-Induced Upregulation of Amyloid-β Influx Transport in an In Vitro BBB Model
Fang Chen,Arijit Ghosh,Arijit Ghosh,Mei Hu,Yan Long,Hong-Bin Sun,Ling-Yi Kong,Hao Hong,Su-Su Tang +8 more
TL;DR: The results suggest that RAGE-NF-κB-PPARγ signaling is involved in regulation of AGEs-induced influx transport of Aβ across the BBB and targeting the signaling pathway could serve as a novel strategy to modify such Aβ transport.
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Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice.
Shun-Chang Fang,Hang Xie,Fang Chen,Mei Hu,Yan Long,Hong-Bin Sun,Ling-Yi Kong,Hao Hong,Su-Su Tang +8 more
TL;DR: Oral administration of simvastatin at 10 or 20mg/kg for 4weeks significantly ameliorated diabetes-associated memory impairment and pronouncedly attenuated amyloidogenesis as well as suppressed neuronal apoptosis in streptozotocin-induced diabetic mice.
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Pharmacokinetics, mass balance, and metabolism of [14C]vicagrel, a novel irreversible P2Y12 inhibitor in humans
Yuandong Zheng,Hua Zhang,Yan Zhan,Yicong Bian,Sheng Ma,Hai-Xian Gan,Xiaojuan Lai,Liu Yongqiang,Yanchun Gong,Liu Xuefang,Hong-Bin Sun,Yongguo Li,Dafang Zhong,Liyan Miao,Xingxing Diao +14 more
TL;DR: Overall, renal elimination plays a crucial role in vicagrel disposition, and the thiophene ring is the predominant metabolic site.
22
Hippocampal PPARδ Overexpression or Activation Represses Stress-Induced Depressive Behaviors and Enhances Neurogenesis
Miao-jin Ji,Xu-Ben Yu,Zhen-lin Mei,Yun-Qi An,Su-Su Tang,Mei Hu,Yan Long,Ming-xing Miao,Qing-Hua Hu,Hong-Bin Sun,Ling-yi Kong,Hao Hong +11 more
TL;DR: The results suggest that hippocampal PPARδ upregulation represses stress-induced depressive behaviors, accompanied by enhancement of neurogenesis in the hippocampi of mice.
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