Hisayoshi Hashimoto
National Cancer Research Institute
9 Papers
43 Citations
Hisayoshi Hashimoto is an academic researcher from National Cancer Research Institute. The author has contributed to research in topics: Hematopoietic stem cell transplantation & Transplantation. The author has an hindex of 7, co-authored 8 publications.
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Papers
Intratumoral IFN-α gene delivery reduces tumor-infiltrating regulatory T cells through the downregulation of tumor CCL17 expression
TL;DR: A novel mechanism of IFN-α-mediated Treg suppression is shown, and combining IFn-α gene therapy with strong CCL17 downregulation could offer a promising strategy for the treatment of cancer.
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Characteristics and outcomes of patients diagnosed with norovirus gastroenteritis after allogeneic hematopoietic stem cell transplantation based on immunochromatography
Ryosuke Ueda,Shigeo Fuji,Shinichiro Mori,Nobuhiro Hiramoto,Hisayoshi Hashimoto,Takashi Tanaka,Kohei Tada,Yujin Kobayashi,Noriyuki Morikawa,Akihito Shinohara,Keiji Okinaka,Akiko Miyagi Maeshima,Saiko Kurosawa,Sung-Won Kim,Takuya Yamashita,Takahiro Fukuda +15 more
TL;DR: In conclusion, IC may be useful in the differential diagnosis of diarrhea after allogeneic HSCT, and could enable the appropriate adjustment of immunosuppressive drugs and prompt preventive measures.
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Interaction of natural killer cells with neutrophils exerts a significant antitumor immunity in hematopoietic stem cell transplantation recipients
TL;DR: It is suggested that neutrophils in tumor prevent NK cells from activation‐induced cell death during HP, thus leading to a significant antitumor effect by NK cells.
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Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation
Hisayoshi Hashimoto,Shigehisa Kitano,Ryosuke Ueda,Ayumu Ito,Kohei Tada,Shigeo Fuji,Takuya Yamashita,Daisuke Tomura,Ikuei Nukaya,Junichi Mineno,Takahiro Fukuda,Shinichiro Mori,Yoichi Takaue,Yuji Heike +13 more
TL;DR: The probable cause of rapid disappearance of TK-cells is suggested to be insufficient in vivo expansion of T k-cells in these patients, and DLI of Tk-cells was safely performed in all three patients.
TH1 cytokines induce senescence in AML.
Hisayoshi Hashimoto,Derya Güngör,Naomi Krickeberg,Johanna Schmitt,Larissa Doll,Marina Schmidt,Sabine Schleicher,Elvira Criado-Moronati,Karin Schilbach +8 more
TL;DR: In this paper , the authors examined the senescence induction of acute myeloid leukemia (AML) cells by PRAME-specific TH1 cells and showed that the supernatants of antigen-stimulated TH1-specific T cells induce the cell lines Kasumi and Nomo-1 through combinative IFN-γ and TNF-α.
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