Hirayasu Kai
University of Tsukuba
54 Papers
220 Citations
Hirayasu Kai is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Kidney disease & Renal function. The author has an hindex of 14, co-authored 38 publications.
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Papers
DOCK2 is involved in the host genetics and biology of severe COVID-19
Ho Namkoong,Ryuya Edahiro,Tomomi Takano,Hiroshi Nishihara,Yuya Shirai,Kyuto Sonehara,Hiromu Tanaka,Shuhei Azekawa,Yohei Mikami,Ho Sim Lee,Takanori Hasegawa,Koji Okudela,Daisuke Okuzaki,Daisuke Motooka,Masahiro Kanai,Tatsuhiko Naito,Kenichi Yamamoto,Qingbo Wang,Ryunosuke Saiki,Rino Ishihara,Yutaka Matsubara,Junko Hamamoto,Hiroyuki Hayashi,Yukihiro Yoshimura,Natsuo Tachikawa,Emmy Yanagita,Takayoshi Hyugaji,Eigo Shimizu,Kotoe Katayama,Yasuhiro Kato,Takayoshi Morita,Kazuhisa Takahashi,Norihiro Harada,Toshio Naito,Makoto Hiki,Yasushi Matsushita,Haruhi Takagi,R. Aoki,Ai Nakamura,Sonoko Harada,Hitoshi Sasano,Hiroki Kabata,Katsunori Masaki,Hirofumi Kamata,Shinnosuke Ikemura,Shotaro Chubachi,Satoshi Okamori,Hideki Terai,Atsuho Morita,Takanori Asakura,Junichi Sasaki,Hiroshi Morisaki,Yoshifumi Uwamino,Kosaku Nanki,Sho Uchida,Shunsuke Uno,Tomoyasu Nishimura,Takashi Ishiguro,Taisuke Isono,Shun Shibata,Yuma Matsui,Chiaki Hosoda,Kenji Takano,Takashi Nishida,Yoichi Kobayashi,Yotaro Takaku,Noboru Takayanagi,Soichiro Ueda,Ai Tada,Masayoshi Miyawaki,Masao Yamamoto,Eriko Yoshida,Reina Hayashi,T. Nagasaka,Sawako Arai,Yutaro Kaneko,Kana Sasaki,Etsuko Tagaya,Masatoshi Kawana,Ken Arimura,Kunihiko Takahashi,Tatsuhiko Anzai,Satoshi Ito,Akifumi Endo,Yuji Uchimura,Yasunari Miyazaki,T. Honda,Tomoya Tateishi,Shuji Tohda,Naoya Ichimura,Kazunari Sonobe,C. Sassa,Jun Nakajima,Yasushi Nakano,Yukiko Nakajima,Ryusuke Anan,Ryosuke Arai,Yuko Kurihara,Yuko Harada,Kazumi Nishio,Tetsuya Ueda,Masanori Azuma,Ryuichi Saito,Toshikatsu Sado,Y. Miyazaki,Ryuichi Sato,Yuki Haruta,Tadao Nagasaki,Yoshinori Yasui,Yoshinori Hasegawa,Yoshikazu Mutoh,Tomoki Kimura,Tomonori Sato,Reoto Takei,Satoshi Hagimoto,Yoichiro Noguchi,Yasuhiko Yamano,Hajime Sasano,S. Ota,Yasushi Nakamori,Kazuhisa Yoshiya,Fukuki Saito,Tomoyuki Yoshihara,Daiki Wada,Hiromu Iwamura,Syuji Kanayama,Shuhei Maruyama,Takashi Yoshiyama,Ken-ichi Ohta,H. Kokuto,Hideo Ogata,Yoshiaki Tanaka,K. Arakawa,Masami Shimoda,Takeshi Osawa,Hiroki Tateno,Isano Hase,Shuichi Yoshida,Shoji Suzuki,Miki Kawada,Hirohisa Horinouchi,Fumitake Saito,Keiko Mitamura,Masao Hagihara,Junichi Ochi,Tomoyuki Uchida,Rie Baba,Daisuke Arai,Takayuki Ogura,Hidenori Takahashi,Shigehiro Hagiwara,Genta Nagao,Shunichiro Konishi,Ichiro Nakachi,K. Murakami,Mitsuhiro Yamada,Hisatoshi Sugiura,Hirohito Sano,Shuichiro Matsumoto,Nozomu Kimura,Yoshinao Ono,Hiroaki Baba,Yusuke Suzuki,Sohei Nakayama,Keita Masuzawa,Shinichi Namba,Ken Suzuki,Yoko Naito,Yu-Chen Liu,Ayako Takuwa,Fuminori Sugihara,James B. Wing,Shuhei Sakakibara,Nobuyuki Hizawa,Takayuki Shiroyama,Satoru Miyawaki,Yusuke Kawamura,Akiyoshi Nakayama,Hirotaka Matsuo,Yuichi Maeda,Takuro Nii,Yoshimi Noda,Takayuki Niitsu,Yuichi Adachi,Takatoshi Enomoto,Saori Amiya,Reina Hara,Yuta Yamaguchi,Teruaki Murakami,Tomoki Kuge,Kinnosuke Matsumoto,Yuji Yamamoto,Makoto Yamamoto,Midori Yoneda,Toshihiro Kishikawa,Shuhei Yamada,Shuhei Kawabata,Noriyuki Kijima,Masatoshi Takagaki,Noa Sasa,Yuya Ueno,Motoyuki Suzuki,Norihiko Takemoto,Hirotaka Eguchi,Takahito Fukusumi,Takao Imai,Munehisa Fukushima,Haruhiko Kishima,Hidenori Inohara,Kazunori Tomono,Kazuto Kato,Meiko Takahashi,Fumihiko Matsuda,Haruhiko Hirata,Yoshito Takeda,Hidefumi Koh,Tadashi Manabe,Yohei Funatsu,Fumimaro Ito,Takahiro Fukui,Keisuke Shinozuka,Sumiko Kohashi,Masatoshi Miyazaki,Tomohisa Shoko,Mitsuaki Kojima,Tomohiro Adachi,Motonao Ishikawa,Kenichiro Takahashi,Takashi Inoue,Toshiyuki Hirano,Keigo Kobayashi,Hatsuyo Takaoka,Kazuyoshi Watanabe,Naoki Miyazawa,Yasuhiro Kimura,Reiko Sado,Hideyasu Sugimoto,Akane Kamiya,Naota Kuwahara,Akiko Fujiwara,Tomohiro Matsunaga,Yoko Sato,Takenori Okada,Y Hirai,Hidetoshi Kawashima,Atsuya Narita,Kazuki Niwa,Yoshiyuki Sekikawa,Koichi Nishi,Masaru Nishitsuji,Mayuko Tani,Junya Suzuki,Hiroki Nakatsumi,Takashi Ogura,Hideya Kitamura,Eri Hagiwara,Kota Murohashi,Hiroko Okabayashi,Takao Mochimaru,Shigenari Nukaga,Ryosuke Satomi,Yoshitaka Oyamada,Nobuaki Mori,Tomoya Baba,Yasutaka Fukui,Mitsuru Odate,Shuko Mashimo,Yasushi Makino,Kazuma Yagi,Mizuha Hashiguchi,Junko Kagyo,Tetsuya Shiomi,Satoshi Fuke,Hiroshi Saito,Tomoya Tsuchida,Shigeki Fujitani,Mumon Takita,Daiki Morikawa,Toru Yoshida,Takehiro Izumo,Minoru Inomata,Naoyuki Kuse,Nobuyasu Awano,Mari Tone,Akihiro Ito,Yoshihiko Nakamura,Kota Hoshino,Jun-ichi Maruyama,Hiroyasu Ishikura,Tohru Takata,Toshio Odani,Masaru Amishima,Takeshi Hattori,Yasuo Shichinohe,Takashi Kagaya,Toshiyuki Kita,Kazuhide Ohta,Satoru Sakagami,Kiyoshi Koshida,Kentaro Hayashi,Tetsuo Shimizu,Yutaka Kozu,Hisato Hiranuma,Yasuhiro Gon,Namiki Izumi,Kaoru Nagata,Ken Ueda,Reiko Taki,Satoko Hanada,Kodai Kawamura,Kazuya Ichikado,K. Nishiyama,Hiroyuki Muranaka,Kazunori Nakamura,Naozumi Hashimoto,Keiko Wakahara,Koji Sakamoto,Norihito Omote,Akira Ando,Nobuhiro Kodama,Yasunari Kaneyama,Shunsuke Maeda,Takashige Kuraki,Takemasa Matsumoto,Koutaro Yokote,Taka-aki Nakada,Ryuzo Abe,Taku Oshima,Tadanaga Shimada,Masahiro Harada,Takeshi Takaha,Hiroshi Ono,Toshihiro Sakurai,Takayuki Shibusawa,Yoshifumi Kimizuka,Akihiko Kawana,Tomoya Sano,Chie Watanabe,Ryohei Suematsu,Hisako Sageshima,Ayumi Yoshifuji,K. Ito,Saeko Takahashi,Kota Ishioka,Morio Nakamura,Makoto Masuda,Aya Wakabayashi,Hiroki Watanabe,Suguru Ueda,Masanori Nishikawa,Yusuke Chihara,May Takeuchi,Keisuke Onoi,Jun Shinozuka,Atsushi Sueyoshi,Yoji Nagasaki,Masaki Okamoto,Sayoko Ishihara,M Shimo,Yoshihisa Tokunaga,Yu Kusaka,Takehiko Ohba,Susumu Isogai,Aki Ogawa,T. Inoue,Satoru Fukuyama,Yoshihiro Eriguchi,Akiko Yonekawa,Keiko Kan-o,Koichiro Matsumoto,Kensuke Kanaoka,Shoichi Ihara,Kiyoshi Komuta,Yoshiaki Inoue,Shigeru Chiba,Kunihiro Yamagata,Yuji Hiramatsu,Hirayasu Kai,Koichiro Asano,Tsuyoshi Oguma,Yoko Ito,Satoru Hashimoto,Masaki Yamasaki,Yukiko Kasamatsu,Yuko Komase,Naoya Hida,Takahiro Tsuburai,Baku Oyama,Minoru Takada,Hidenori Kanda,Yuichiro Kitagawa,Tetsuya Fukuta,Takahito Miyake,Sho Yoshida,Shinji Ogura,Shinji Abe,Yutaka Kono,Yuki Togashi,Hiroyuki Takoi,Ryota Kikuchi,Shinichi Ogawa,Tomouki Ogata,Shoichiro Ishihara,Arihiko Kanehiro,Shinji Ozaki,Yasuko Fuchimoto,Sae Wada,Nobukazu Fujimoto,Kei Nishiyama,Mariko Terashima,Satoru Beppu,Kosuke Yoshida,Osamu Narumoto,Hideaki Nagai,N. Ooshima,Mitsuru Motegi,Akira Umeda,Kazuya Miyagawa,Hisato Shimada,Mayu Endo,Yoshiyuki Ohira,M. Watanabe,Sumito Inoue,Akira Igarashi,Masamichi Sato,Hironori Sagara,Akihiko Tanaka,Shin Ohta,Tomoyuki Kimura,Yoko Shibata,Yoshinori Tanino,Takefumi Nikaido,Hiroyuki Minemura,Yuki Sato,Yuichiro Yamada,Takuya Hashino,Masatoshi Shinoki,Hajime Iwagoe,Hiroshi Takahashi,Kazuhiko Fujii,Hiroto Kishi,Masayuki Kanai,Tomonori Imamura,T. Yamashita,Masakiyo Yatomi,Toshitaka Maeno,Shinichi Hayashi,Mai Takahashi,Mizuki Kuramochi,Isamu Kamimaki,Yoshiteru Tominaga,Tomoo Ishii,Mitsuyoshi Utsugi,Akihiro Ono,Toru Tanaka,Takeru Kashiwada,Kazue Fujita,Yoshinobu Saito,Masahiro Seike,Hiroko Watanabe,Hiroto Matsuse,Norio Kodaka,Chihiro Nakano,Takeshi Oshio,Takatomo Hirouchi,Shohei Makino,Moritoki Egi,Koichi Matsuda,Yuji Yamanashi,Yoichi Furukawa,Takayuki Morisaki,Yoshinori Murakami,Yoichiro Kamatani,Kaori Muto,Akiko Nagai,Wataru Obara,Ken Yamaji,Satoshi Asai,Yasuo Takahashi,Takao Suzuki,Nobuaki Sinozaki,Hiroki Yamaguchi,Shiro Minami,Shigeo Murayama,Kozo Yoshimori,Satoshi Nagayama,Daisuke Obata,Masahiko Higashiyama,Akihide Masumoto,Yukihiro Koretsune,Yosuke Omae,Yasuhito Nannya,Takafumi Ueno,Kazuhiko Katayama,Masumi Ai,Yoshinori Fukui,Atsushi Kumanogoh,Toshiro Sato,Naoki Hasegawa,Katsushi Tokunaga,Makoto Ishii,Ryuji Koike,Yuko Kitagawa,Akinori Kimura,Seiya Imoto,Satoru Miyano,Seishi Ogawa,Takanori Kanai,Koichi Fukunaga,Yukinori Okada +509 more
TL;DR: In this article , the authors conducted a genome-wide association study (GWAS) involving 2,393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3,289 unaffected controls.
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Critical role of DNAX accessory molecule-1 (DNAM-1) in the development of acute graft-versus-host disease in mice
Tsukasa Nabekura,Kazuko Shibuya,Eri Takenaka,Hirayasu Kai,Kai Shibata,Yumi Yamashita,Kyoichi Harada,Satoko Tahara-Hanaoka,Shin-ichiro Honda,Akira Shibuya +9 more
TL;DR: It is shown that mice that received allogeneic splenocytes deficient in DNAX accessory molecule-1 (DNAM-1) had significantly milder GVHD and lower mortality and that DNAM- 1 is an ideal molecular target for therapeutic approaches to GV HD.
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LFA-1 decreases the antigen dose for T cell activation in vivo.
Yinan Wang,Kazuko Shibuya,Yumi Yamashita,Jun Shirakawa,Kai Shibata,Hirayasu Kai,Tadashi Yokosuka,Takashi Saito,Shin-ichiro Honda,Satoko Tahara-Hanaoka,Akira Shibuya +10 more
TL;DR: It is shown that, although collagen-induced arthritis (CIA) could not be induced by immunization and challenge with a standard amount of type-II collagen in LFA-1-deficient mice, a higher dose of the antigen did induce CIA in the absence of L FA-1, suggesting that LFA -1 decreases the threshold of TCR signal for T cell activation in vivo as well as in vitro.
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Health-related quality of life and prognosis in patients with chronic kidney disease: a 3-year follow-up study
Reiko Okubo,Hirayasu Kai,Masahide Kondo,Chie Saito,Keigyou Yoh,Naoki Morito,Joichi Usui,Kunihiro Yamagata +7 more
TL;DR: Quality-adjustment weights in CKD patients were associated with not only disease progression such as initiation of dialysis treatment and incidence of CVD events and all-cause death, but also the level of proteinuria at baseline.
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Critical role of M. tuberculosis for dendritic cell maturation to induce collagen-induced arthritis in H-2b background of C57BL/6 mice.
Hirayasu Kai,Kazuko Shibuya,Yinan Wang,Hirotaka Kameta,Tomie Kameyama,Satoko Tahara-Hanaoka,Akitomo Miyamoto,Shin-ichiro Honda,Isao Matsumoto,Akio Koyama,Takayuki Sumida,Akira Shibuya +11 more
TL;DR: Results suggested that high dose of M. tuberculosis were required for maturation of DC enough to prime CD4+ helper T cells specific to CII antigen in DLN of H‐2b background of C57BL/6 mice.
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