Electron spectroscopy of functional organic thin films: Deep insights into valence electronic structure in relation to charge transport property

Biological Dispersion and the Design of Site-Specific Protein Therapeutic Systems.- Recombinant Ligand-Toxin Conjugates, Domain Engineering and the Search for Targeted Pharmaceuticals.- Extravascular Diffusion and Convection of Antibodies in Tumors.- Antitumor Effects of Six Ricin A-Chain Immunotoxins of Potential Use in the Treatment of Hodgkin's Disease.- Enhancement of Hormone Activity by Monoclonal Antibodies.- Modeling of Cell Membrane Targeting: Specific Recognition, Binding and Protein Domain Formation in Ligand- Containing Model Biomembranes.- Endocytosis of Cell Surface Molecules and Intracellular Delivery of Materials Encapsulated in Targeted Liposomes.- Tissue Specific Serum Opsonins and Phagocytosis of Liposomes.- Liposome Targeting to Tumor Cells In Vivo.- Stabilization of Lipid Microstructures: Fundamentals and Applications.- Non-Ionic Surfactant Vesicles as Carriers of Doxorubicin.- Targeted Therapy of Liver Carcinoma.- Drug Delivery Systems: The Industrial View.- Controlled Delivery to the Brain.- Polymeric Delivery Systems.- Participants Photograph.- Contributors.

Targeting of drugs 2 : optimization strategies

Molecular packing in lead arachidate [(C19H39COO)2Pb] Langmuir Blodgett monolayer films transferred to glass substrates has been investigated using x‐ray photoemission spectroscopy. It was observed that the degree of salt formation was a sensitive function of the subphase pH reaching a maximum at a pH of nearly 5.8. The loss features in the C 1s core level spectra of the films were clearly defined for films consisting of purely metal salt of arachidic acid while they became progressively diffused as the subphase pH was reduced. The blurring of the C 1s loss features has been explained as arising due to disorder introduced into the alkyl chains of lead arachidate molecules by the evaporation of acid molecules under ultrahigh vacuum. This leads to changes in the quasi one‐dimensional electronic band structure in such molecular crystal films. A comparison is made with results obtained on cadmium arachidate and arachidic acid monolayer Langmuir Blodgett films. It is thus shown that molecular packing in Langmu...

Molecular packing in Langmuir Blodgett films by core level loss spectroscopy

The study of self-organized two-dimensional structures can furnish new ideas for future molecular devices, especially if the self-organization of the structures can be modulated by external agents, like an exogenous electric field.

Fluorescence Image Analysis of the Spatial Organization of Lipid Layers

Drug delivery systems are designed to assist, accelerate, and control transport of pharmacologically active agents from sites of administration to specified targets in organs and tissues. So-called controlled drug delivery systems are intended to maintain continuously efficacious drug concentrations in vivo, either locally or systemically, over longer time periods. They should provide constant dosage levels above a minimum level of efficacy yet below mandated toxicity levels — a significant advantage over many conventional systemically administered formulations. Site-specific targeting of drugs, particularly those agents which prove highly toxic in small doses, can be utilized to maintain therapeutically relevant levels of drug to targeted tissue at a localized site specifically without systemic toxicity. Pharmaceutical problems, such as avoidance of first-pass effects in the liver, spleen, and filtration organs, solubility and stability problems in certain formulations, as well as the reliability of long-term delivery within a single device are important advantages in clinical applications of controlled and targeted drug delivery systems.

Modeling of Cell Membrane Targeting: Specific Recognition, Binding, and Protein Domain Formation in Ligand-Containing Model Biomembranes

One-dimensional energy band dispersion in Langmuir-Blodgett films determined by angle-resolved photoemission with synchrotron radiation

Lateral molecular organization and order in monomolecular layers

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One-dimensional energy band dispersion in Langmuir-Blodgett films determined by angle-resolved photoemission with synchrotron radiation

Lateral molecular organization and order in monomolecular layers