Effect of dry-out on the fouling of PVDF and PTFE membranes under conditions simulating intermittent seawater membrane distillation (SWMD)

Kozeny-Carman permeability equation is an important relation for the determination of permeability in porous media. In this study, the permeabilities of porous media that contains rectangular rods are determined, numerically. The applicability of Kozeny-Carman equation for the periodic porous media is investigated and the effects of porosity and pore to throat size ratio on Kozeny constant are studied. The continuity and Navier-Stokes equations are solved to determine the velocity and pressure fields in the voids between the rods. Based on the obtained flow field, the permeability values for different porosities from 0.2 to 0.9 and pore to throat size ratio values from 1.63 to 7.46 are computed. Then Kozeny constants for different porous media with various porosity and pore to throat size ratios are obtained and a relationship between Kozeny constant, porosity and pore to throat size ratio is constructed. The study reveals that the pore to throat size ratio is an important geometrical parameter th...

Determination of Kozeny Constant Based on Porosity and Pore to Throat Size Ratio in Porous Medium with Rectangular Rods

Thermal performance of a thin flat heat pipe with grooved porous structure

Background Heart transplantation in infants and children is an accepted therapy for end-stage heart failure, but donor organ availability is low and always uncertain. Mechanical circulatory support is another standard option, but there is a lack of intracorporeal devices due to size and functional range. The purpose of this study was to evaluate the in vivo performance of our initial prototype of a pediatric continuous-flow total artificial heart (P-CFTAH), comprising a dual pump with one motor and one rotating assembly, supported by a hydrodynamic bearing. Methods In acute studies, the P-CFTAH was implanted in 4 lambs (average weight: 28.7 ± 2.3 kg) via a median sternotomy under cardiopulmonary bypass. Pulmonary and systemic pump performance parameters were recorded. Results The experiments showed good anatomical fit and easy implantation, with an average aortic cross-clamp time of 98 ± 18 minutes. Baseline hemodynamics were stable in all 4 animals (pump speed: 3.4 ± 0.2 krpm; pump flow: 2.1 ± 0.9 liters/min; power: 3.0 ± 0.8 W; arterial pressure: 68 ± 10 mm Hg; left and right atrial pressures: 6 ± 1 mm Hg, for both). Any differences between left and right atrial pressures were maintained within the intended limit of ±5 mm Hg over a wide range of ratios of systemic-to-pulmonary vascular resistance (0.7 to 12), with and without pump-speed modulation. Pump-speed modulation was successfully performed to create arterial pulsation. Conclusion This initial P-CFTAH prototype met the proposed requirements for self-regulation, performance, and pulse modulation.

/pdf/early-in-vivo-experience-with-the-pediatric-continuous-flow-3nm35a6o9c.pdf

Early in vivo experience with the pediatric continuous-flow total artificial heart.

Children with end-stage lung failure awaiting lung transplant would benefit from improvements in artificial lung technology allowing for wearable pulmonary support as a bridge-to-transplant therapy. In this work, we designed, fabricated, and tested the Pediatric MLung-a dual-inlet hollow fiber artificial lung based on concentric gating, which has a rated flow of 1 L/min, and a pressure drop of 25 mm Hg at rated flow. This device and future iterations of the current design are designed to relieve pulmonary arterial hypertension, provide pulmonary support, reduce ventilator-associated injury, and allow for more effective therapy of patients with end-stage lung disease, including bridge-to-transplant treatment.

Low-Resistance, Concentric-Gated Pediatric Artificial Lung for End-Stage Lung Failure.

Darcy Permeability of Hollow Fiber Bundles Used in Blood Oxygenation Devices.

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Darcy Permeability of Hollow Fiber Bundles Used in Blood Oxygenation Devices.