Heesun Choi
Seoul National University
5 Papers
Heesun Choi is an academic researcher from Seoul National University. The author has contributed to research in topics: Mitochondrion & Biology. The author has an hindex of 5, co-authored 5 publications.
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Papers
Acetylation changes tau interactome to degrade tau in Alzheimer’s disease animal and organoid models
Heesun Choi,Haeng Jun Kim,Jinhee Yang,Sehyun Chae,Wonik Lee,Sunwoo Chung,Ji Soo Kim,Hyunjung Choi,Hyeseung Song,Chang Kon Lee,Jae Hyun Jun,Yong Jae Lee,Kyunghyeon Lee,Semi Kim,Hye ri Sim,Young Il Choi,Keun Ho Ryu,Jong-Chan Park,Dong-Joon Lee,Sun Ho Han,Daehee Hwang,Jangbeen Kyung,Inhee Mook-Jung +22 more
TL;DR: A histone deacetylase 6 (HDAC6) inhibitor, CKD‐504, changed the tau interactome dramatically to degrade pathological tau not only in AD animal model (ADLPAPT) brains containing both amyloid plaques and neurofibrillary tangles but also in AD patient‐derived brain organoids, leading to the recovery of synaptic pathology and cognitive decline in the AD LPAPT mice.
103
Mitochondrial ATP synthase activity is impaired by suppressed O-GlcNAcylation in Alzheimer's disease
Moon Yong Cha,Hyun Jin Cho,Chaeyoung Kim,Yang Ouk Jung,Min Jueng Kang,Melissa E. Murray,Hyun Seok Hong,Young Joo Choi,Heesun Choi,Dong Kyu Kim,Hyunjung Choi,Ji Soo Kim,Dennis W. Dickson,Hyun Kyu Song,Jin Won Cho,Eugene C. Yi,Jungsu Kim,Seok Min Jin,Inhee Mook-Jung +18 more
TL;DR: The results indicate that Aβ-mediated reduction of ATP synthase activity in AD pathology results from direct binding between Aβ and ATP synth enzyme and inhibition of O-GlcNAcylation of Thr432 residue on ATP5A.
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Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model
Sung Hoon Baik,Moon Yong Cha,Young-Min Hyun,Hansang Cho,Bashar Hamza,Dong Kyu Kim,Sun Ho Han,Heesun Choi,Kyung Ho Kim,Minho Moon,Jeewoo Lee,Minsoo Kim,Minsoo Kim,Daniel Irimia,Inhee Mook-Jung +14 more
TL;DR: Using a 2-photon microscopy to reveal that neutrophils infiltrate brain and migrate toward amyloid plaques in a mouse model of Alzheimer's disease suggests a new molecular process underlying the pathophysiology of Alzheimer’s disease.
Annexin A1 restores Aβ1-42 -induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway.
Jong-Chan Park,Sung Hoon Baik,Sun Ho Han,Hyun Jin Cho,Hyunjung Choi,Haeng Jun Kim,Heesun Choi,Wonik Lee,Dong Kyu Kim,Inhee Mook-Jung +9 more
TL;DR: It is suggested that ANXA1 restores Aβ42‐induced BBB disruption through inhibition of RhoA‐ROCK signaling pathway and is proposed as a therapeutic reagent, protecting against the breakdown of the BBB in AD.
HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation
Ji Yon Kim,So Youn Woo,Young Bin Hong,Heesun Choi,Ji Soo Kim,Hyunjung Choi,Inhee Mook-Jung,Nina Ha,Jangbeen Kyung,Soo Kyung Koo,Sung Chul Jung,Byung Ok Choi +11 more
TL;DR: The results suggest that the neurons derived from patient-specific iPSCs can be used in drug screening including HDAC6 inhibitors targeting peripheral neuropathy.