43 Papers
68 Citations
Hao Hu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Chemistry & Methylation. The author has an hindex of 12, co-authored 35 publications. Previous affiliations of Hao Hu include Wuhan University & University of Georgia.
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Papers
Identification of a cellularly active SIRT6 allosteric activator.
Zhimin Huang,Jiajun Zhao,W. Deng,Yanwen Chen,Jialin Shang,Kun Song,Liang Zhang,Chengxiang Wang,Shaoyong Lu,Xiuyan Yang,Bin He,Jinrong Min,Hao Hu,Minjia Tan,Jianrong Xu,Qiufen Zhang,Jie Zhong,Xiaoxiang Sun,Zhiyong Mao,Hou-Wen Lin,M. Xiao,Y.E. Chin,Hualiang Jiang,Ying Xu,Guo-Qiang Chen,Jian Zhang +25 more
TL;DR: The use of an allosteric drug-design method resulted in the identification of a first-in-class cellularly active SIRT6 activator that induces cell-cycle arrest in the G0–G1 phase, thus suppressing proliferation in human hepatocellular carcinoma cells.
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Small Molecule Inhibitors of Protein Arginine Methyltransferases
TL;DR: Discovery and evaluation of potent, isoform-selective, cell-permeable and in vivo-active PRMT modulators will continue to be an active arena of research in years ahead.
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Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis
Ying Dong,Hao Hu,Xuan Zhang,Yunkai Zhang,Xin Sun,Han-Min Wang,Wei-Juan Kan,Minjia Tan,Hong Shi,Yinliang Zang,Jia Ji Li +10 more
TL;DR: Zhang et al. as discussed by the authors showed that AMP activation by metformin relieves the repressive H3K9me2-mediated silencing of epithelial genes (e.g., CDH1) during EMT processes and inhibits lung cancer metastasis.
Light-induced primary amines and o-nitrobenzyl alcohols cyclization as a versatile photoclick reaction for modular conjugation.
An-Di Guo,Dan Wei,Hui-Jun Nie,Hao Hu,Chengyuan Peng,Shao-Tong Li,Yan Kenian,Zhou Binshan,Feng Lei,Chao Fang,Minjia Tan,Ruimin Huang,Xiao-Hua Chen +12 more
TL;DR: PANAC photoclick is robust for direct diversification of pharmaceuticals and biorelevant molecules, lysine-specific modifications of unprotected peptides and native proteins in vitro, temporal profiling of endogenous kinases and organelle-targeted labeling in living systems and provides a versatile platform for organic synthesis, bioconjugation, medicinal chemistry, chemical biology and materials science.
Genetically Encoded Residue-Selective Photo-Crosslinker to Capture Protein-Protein Interactions in Living Cells
Wei Hu,Yi Yuan,Cai-Hu Wang,Hong-Tao Tian,An-Di Guo,Hui-Jun Nie,Hao Hu,Minjia Tan,Zhuo Tang,Xiao-Hua Chen +9 more
TL;DR: This photo-crosslinker enables the capture of elusive enzyme-substrate interaction with directly interacting lysine and validation of acetylation site of the substrate and represents higher spatiotemporal resolution, accuracy, and reliability for investigating dynamic, transient, and weak protein-protein interactions in living systems.
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