Hans G. Bone
University of Münster
20 Papers
294 Citations
Hans G. Bone is an academic researcher from University of Münster. The author has contributed to research in topics: Sepsis & Pulmonary artery. The author has an hindex of 12, co-authored 20 publications. Previous affiliations of Hans G. Bone include University of Texas Medical Branch.
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Papers
Nitric Oxide Synthase Inhibition Restores Hypoxic Pulmonary Vasoconstriction in Sepsis
Stefanie R. Fischer,Donald J. Deyo,Hans G. Bone,Roy McGuire,Lillian D. Traber,Daniel L. Traber +5 more
TL;DR: It is concluded that L-NMMA improves but does not restore HPV, indicating that other vasodilatory mediators besides NO also influence HPV in sepsis.
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Pyridoxalated hemoglobin polyoxyethylene conjugate reverses hyperdynamic circulation in septic sheep
Hans G. Bone,Paul J. Schenarts,Stefanie R. Fischer,Roy McGuire,Lillian D. Traber,Daniel L. Traber +5 more
TL;DR: No side effects after PHP infusion are found that would limit the use of PHP as a nitric oxide scavenger in sepsis, and none of the investigated blood chemistry variables showed any changes indicative of impaired organ function afterPHP infusion.
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Oxalated pyridoxalated hemoglobin polyoxyethylene conjugate normalizes the hyperdynamic circulation in septic sheep
Hans G. Bone,Paul J. Schenarts,Michael Booke,Roy McGuire,Donald D. Harper,Lillian D. Traber,Daniel L. Traber +6 more
TL;DR: The infusion of low doses of pyridoxalated hemoglobin polyoxyethylene conjugate in septic sheep reverses the hyperdynamic circulatory state and may affect the nitric oxide synthase and endothelin systems.
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Hemodynamic effects of exogenous adrenomedullin in healthy and endotoxemic sheep.
Martin Westphal,Henning D. Stubbe,Hans G. Bone,Fritz Daudel,Sebastian Vocke,Hugo Van Aken,Michael Booke +6 more
TL;DR: It is confirmed that AM produces a hyperdynamic circulation, in the presence and absence of systemic inflammation, and exogenous AM could possibly be a useful adjunct in the common setting of sepsis-associated pulmonary hypertension.
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Continuous infusion of pyridoxalated hemoglobin polyoxyethylene conjugate in hyperdynamic septic sheep
Hans G. Bone,Stefanie R. Fischer,Paul J. Schenarts,Roy McGuire,Lillian D. Traber,Daniel L. Traber +5 more
TL;DR: Investigation of the effects of a continuous low-dose infusion of modified hemoglobin during ovine hyperdynamic sepsis found it can normalize systemic vascular resistance and MAP for long periods without deterioration of regional blood flow or bacterial clearance.
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