Hannah B. Pooley
University of Sydney
7 Papers
17 Citations
Hannah B. Pooley is an academic researcher from University of Sydney. The author has contributed to research in topics: Paratuberculosis & Vaccination. The author has an hindex of 2, co-authored 3 publications.
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Papers
The humoral immune response is essential for successful vaccine protection against paratuberculosis in sheep
Hannah B. Pooley,Douglas J. Begg,Karren M. Plain,Richard Whittington,Auriol C. Purdie,Kumudika de Silva +5 more
TL;DR: The timing and strength of the humoral immune response after vaccination against paratuberculosis in sheep directly relates to subsequent infection status, and an initial strong IgG1 response following vaccination was crucial to prevent infection.
A Rapid Method for Quantifying Viable Mycobacterium avium subsp. paratuberculosis in Cellular Infection Assays
Hannah B. Pooley,Kumudika de Silva,Auriol C. Purdie,Douglas J. Begg,Richard Whittington,Karren M. Plain +5 more
TL;DR: This method will be important for vaccine and antimicrobial screening work, as it will allow a greater number of candidates to be screened in the same amount of time, which will increase the likelihood that a favorable candidate will be found to be subjected to further testing.
17
A framework for evaluation of on-farm mastitis diagnostics in Australia.
TL;DR: In this paper, the authors evaluate the suitability of on-farm mastitis diagnostics to inform mastitis treatment decision-making in a timely and cost-effective manner, and identify multiple trade-offs, both with regard to scientific criteria and with regards to convenience criteria.
9
Integrated vaccine screening system: using cellular functional capacity in vitro to assess genuine vaccine protectiveness in ruminants.
Hannah B. Pooley,Karren M. Plain,Auriol C. Purdie,Douglas J. Begg,Richard Whittington,Kumudika de Silva +5 more
TL;DR: It is hypothesised that the effectiveness of vaccine-induced immune responses mounted in vivo could be gauged by assessing the ability of immune cells to 'control' an in vitro infection, and has the potential to gauge actual protectiveness, or lack thereof, of a vaccine.
5
Correlates of vaccine protection against Mycobacterium avium sub-species paratuberculosis infection revealed in a transcriptomic study of responses in Gudair® vaccinated sheep
Auriol C. Purdie,Karren M. Plain,Hannah B. Pooley,Douglas J. Begg,Kumudika de Silva,Richard Whittington +5 more
TL;DR: In this article , a transcriptomics approach was used to identify white blood cell gene expression changes in vaccinated, MAP-exposed Merino sheep with a protective response in comparison to those vaccinated animals that failed to develop immunity to MAP infection.