Hanfeng Guan
Huazhong University of Science and Technology
28 Papers
26 Citations
Hanfeng Guan is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Osteoclast & RANKL. The author has an hindex of 14, co-authored 22 publications.
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Papers
Strontium (Sr) and silver (Ag) loaded nanotubular structures with combined osteoinductive and antimicrobial activities.
Hao Cheng,Wei Xiong,Zhong Fang,Hanfeng Guan,Wei Wu,Yong Li,Yong Zhang,Mario Moises Alvarez,Biao Gao,Kaifu Huo,Jiangwen Xu,Na Xu,Chengcheng Zhang,Jijiang Fu,Ali Khademhosseini,Feng Li +15 more
TL;DR: In vivo experiments showed that the Sr-loaded samples accelerated the formation of new bone in both osteoporosis and bone defect models, as confirmed by X-ray, Micro-CT evaluation, and histomorphometric analysis of rats implanted with NT-Ag.
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Inhibition of PRMT5 suppresses osteoclast differentiation and partially protects against ovariectomy-induced bone loss through downregulation of CXCL10 and RSAD2
TL;DR: It is found thatPRMT5 is an activator of osteoclast differentiation and inhibition of PRMT5 partially suppressed osteoc lastogenesis through downregulation of CXCL10 and RSAD2.
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Effects of Taxifolin on Osteoclastogenesis in vitro and in vivo.
TL;DR: The results indicated that taxifolin inhibits osteoclastogenesis via regulation of modulation of several RANKL signaling pathways, and may be considered as a potential alternative therapeutic agent for treating osteoporosis-related diseases.
Epoxyeicosanoids suppress osteoclastogenesis and prevent ovariectomy-induced bone loss
TL;DR: Findings demonstrate that EETs inhibit osteoclastogenesis through modulation of multiple pathways both upstream and downstream of RANKL signaling.
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Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss
TL;DR: The results demonstrate that amlexanox suppresses osteoclastogenesis and prevents OVX-induced bone loss, and may be considered as a new therapeutic candidate for osteocline-related diseases, such as osteoporosis and rheumatoid arthritis.